Fast MacMillan’s Imidazolidinone-Catalyzed Enantioselective Synthesis of Polyfunctionalized 4-Isoxazoline Scaffolds
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DOI: 10.1021/acsomega.2c03477
Abstract: The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated. The use of a second-generation MacMillan catalyst as hydrochloride salt consistently accelerated the reaction… read more here.
Keywords: enantioselective synthesis; imidazolidinone catalyzed; macmillan imidazolidinone; synthesis polyfunctionalized ... See more keywords