Comparing Hydrogen Deuterium Exchange and Fast Photochemical Oxidation of Proteins: a Structural Characterisation of Wild-Type and ΔN6 β2-Microglobulin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1007/s13361-018-2067-y
Abstract: AbstractHydrogen deuterium exchange (HDX) coupled to mass spectrometry (MS) is a well-established technique employed in the field of structural MS to probe the solvent accessibility, dynamics and hydrogen bonding of backbone amides in proteins. By… read more here.
Keywords: oxidation proteins; deuterium exchange; fast photochemical; photochemical oxidation ... See more keywords
Investigating Daptomycin-Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05222
Abstract: Daptomycin is a cyclic lipopeptide antibiotic that targets the lipid membrane of Gram-positive bacteria. Membrane fluidity and charge can affect daptomycin activity, but its mechanisms are poorly understood because it is challenging to study daptomycin… read more here.
Keywords: photochemical oxidation; fast photochemical; membrane interactions; oxidation peptides ... See more keywords
Investigating Antimicrobial Peptide-Membrane Interactions Using Fast Photochemical Oxidation of Peptides in Nanodiscs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.1c00252
Abstract: Antimicrobial peptides (AMPs) are an important part of the innate immune system and demonstrate promising applications in the fight against antibiotic-resistant infections due to their unique mechanism of targeting bacterial membranes. However, it is challenging… read more here.
Keywords: oxidation; investigating antimicrobial; antimicrobial peptide; photochemical oxidation ... See more keywords
Fast Photochemical Oxidation of Proteins Coupled with Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Protein and peptide letters"
DOI: 10.2174/0929866526666181128124554
Abstract: BACKGROUND Determination of the composition and some structural features of macromolecules can be achieved by using structural proteomics approaches coupled with mass spectrometry (MS). One approach is hydroxyl radical protein footprinting whereby amino-acid side chains… read more here.
Keywords: protein; mass spectrometry; mass; coupled mass ... See more keywords