Pharmacokinetics and Bioequivalence Evaluation of 2 Olmesartan Medoxomil and Amlodipine Besylate Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1086
Abstract: Combined antihypertensive drugs have become the basic method of treating hypertension. Olmesartan and amlodipine, as representative drugs of angiotensin receptor blockers and calcium channel blockers, were developed as a compound formulation for antihypertensive treatment. The… read more here.
Keywords: time; fasting fed; fed conditions; bioequivalence ... See more keywords
Pharmacokinetics and Bioequivalence of Single‐Oral‐Dose Linagliptin: A Randomized, 2‐Period Crossover Trial in Chinese Healthy Subjects Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1104
Abstract: The bioequivalence of the reference and test linagliptin formulations was assessed in healthy Chinese subjects under fasting and fed conditions. The study was designed as a single‐dose, randomized, open‐label, 2‐period crossover study with a 35‐day… read more here.
Keywords: fasting fed; period; reference; test ... See more keywords
Pharmacokinetics and Bioequivalence of 2 Safinamide Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1157
Abstract: To assess the bioequivalence of a generic safinamide tablet (test) vs a brand‐name safinamide tablet (reference) and effects of food on the pharmacokinetics of safinamide in healthy Chinese subjects, a single‐center, single‐dose, randomized, open‐label, 2‐preparation,… read more here.
Keywords: time; fasting fed; chinese volunteers; fed conditions ... See more keywords
Pharmacokinetics, Bioequivalence, and Safety of 2 Formulations of Hydroxychloroquine Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1166
Abstract: The purpose of this trial was to evaluate the pharmacokinetics (PK), bioequivalence (BE), and safety of 2 preparations of hydroxychloroquine (200‐mg tablet) under fasting and fed conditions. A total of 180 subjects (fasting condition: n… read more here.
Keywords: safety; fasting fed; pharmacokinetics bioequivalence; fed conditions ... See more keywords
Bioequivalence of Pomalidomide Capsules in Fasting and Fed States in Healthy Male Volunteers: A Randomized, Open, Single‐Dose, Biperiodic, Double‐Crossover Study
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DOI: 10.1002/cpdd.1173
Abstract: This study evaluated the safety, pharmacokinetic parameters, and bioequivalence (BE) of pomalidomide (POM) capsules (specification: 4 mg) acquired from 2 sponsors (test [T] and reference [R]), under fasting and fed conditions. A single‐center, randomized, open‐label,… read more here.
Keywords: single dose; fasting fed; fed states; concentration ... See more keywords
Bioequivalence and Pharmacokinetic Profiles of 2 Trimetazidine Modified‐release Tablets Under Fasting and Fed Conditions in Chinese Healthy Subjects
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DOI: 10.1002/cpdd.1200
Abstract: This study aims to assess the bioequivalence of test and reference formulations of trimetazidine dihydrochloride in healthy Chinese volunteers under fasting and fed conditions, and to determine the effect of food on the pharmacokinetic profiles… read more here.
Keywords: fasting fed; fed conditions; profiles trimetazidine; bioequivalence ... See more keywords
Pharmacokinetics, Bioequivalence, and Safety Evaluation of Dienogest in Healthy Subjects Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1215
Abstract: Dienogest is effective in reducing endometriosis‐related pain symptoms. This study aims to investigate and compare the pharmacokinetic profiles and safety of test formulations to reference formulations of dienogest in healthy Chinese female volunteers under fasting… read more here.
Keywords: time; safety; fasting fed; concentration ... See more keywords
Pharmacokinetic and Bioequivalence Studies of 2 Metformin Glibenclamide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1219
Abstract: The rational combination of oral antidiabetic agents is more likely to provide better glycemic control than monotherapy. Metformin glibenclamide tablets can be used as second‐line therapy for patients with type 2 diabetes mellitus who cannot… read more here.
Keywords: time; fasting fed; fed conditions; glibenclamide tablets ... See more keywords
Pharmacokinetics and Bioequivalence of 2 Nifedipine Controlled-Release Tablets: A Randomized, Single-Dose, 2-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions.
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DOI: 10.1002/cpdd.1258
Abstract: The aim of this study was to evaluate the bioequivalence of generic nifedipine controlled-release tablet compared to branded product under fasting and fed conditions. A randomized, single-dose, 2-period, crossover study with a 7-day washout period… read more here.
Keywords: fasting fed; period; nifedipine; concentration ... See more keywords
The Pharmacokinetics and Bioequivalence of Desvenlafaxine Succinate in Chinese Healthy Subjects Under Fasting and Fed States.
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DOI: 10.1002/cpdd.1272
Abstract: Desvenlafaxine succinate is a selective serotonin-norepinephrine reuptake inhibitor for the treatment of major depressive disorder. The pharmacokinetic profile of desvenlafaxine succinate at the clinically recommended dose of 50 mg in Chinese healthy subjects has been reported… read more here.
Keywords: fasting fed; desvenlafaxine succinate; pharmacokinetics bioequivalence; chinese healthy ... See more keywords
Use of the oral sugar test in ponies when performed with or without prior fasting
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DOI: 10.1111/evj.12607
Abstract: BACKGROUND It is recommended that the oral sugar test (OST) for insulin dysregulation (ID) be performed after an overnight fast, but fasting is impractical in ponies kept solely at pasture. There are few data on… read more here.
Keywords: insulin; fasting fed; prior fasting; test ... See more keywords