Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.038
Abstract: Liposomal fasudil as a treatment for cerebral ischemia/reperfusion (I/R) injury has been demonstrated to be effective in animal models due to the high accumulation of liposomes in damaged brain tissue. However, it is still unclear… read more here.
Keywords: liposomal fasudil; fasudil; treatment; release rate ... See more keywords
Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.10.002
Abstract: OBJECTIVE Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The… read more here.
Keywords: induced nephrotoxicity; fasudil; group; dox ... See more keywords
Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01255
Abstract: Hybrid compounds containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids were designed with the aid of docking and molecular mechanics studies. Following the synthesis of the… read more here.
Keywords: fasudil; hybrid fasudil; multitarget; multitarget hybrid ... See more keywords
Protective Effect of Fasudil on Hydrogen Peroxide-Induced Oxidative Stress Injury of H9C2 Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Disease Markers"
DOI: 10.1155/2021/8177705
Abstract: Objective Oxidative damage is a pathological factor that causes cardiovascular damage in the clinic and is increasingly serious. This study focused on the effect of fasudil on H2O2-induced oxidative damage in cardiomyocytes. Materials and Methods… read more here.
Keywords: h2o2; group; h2o2 group; h9c2 cardiomyocytes ... See more keywords
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
Sign Up to like & getrecommendations! Published in 2017 at "Stroke"
DOI: 10.1161/strokeaha.116.015013
Abstract: Background and Purpose— We sought to compare the effect of chronic treatment with commonly tolerated doses of Fasudil, a specific RhoA kinase (ROCK) inhibitor, and simvastatin (with pleiotropic effects including ROCK inhibition) on cerebral cavernous… read more here.
Keywords: fasudil; simvastatin; rhoa kinase; ccm1 msh2 ... See more keywords
Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223232
Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant cancers and the treatment options for this disease are limited and generally not effective. ROCK has been reported to be highly expressed in many cancer types… read more here.
Keywords: fasudil; lip fasudil; hepatocellular carcinoma; anti tumor ... See more keywords
In vitro inhibition of proliferation, migration and epithelial-mesenchymal transition of human lens epithelial cells by fasudil.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.08.02
Abstract: AIM To study the potential role of fasudil as a treatment for posterior capsular opacification (PCO) of the human crystalline lens. METHODS Human lens epithelial cells (HLECs; line SRA01/04) was exposed to transforming growth factor-β2… read more here.
Keywords: proliferation migration; fasudil; proliferation; migration ... See more keywords
Fasudil protects against adriamycin-induced acute heart injury by inhibiting oxidative stress, apoptosis and cellular senescence.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220729103430
Abstract: BACKGROUND The clinical utility of Adriamycin (ADR) is limited due to its toxicity, particularly cardiotoxicity. Therefore, effective cardioprotective adjuvants to minimize ADR-induced acute cardiotoxicity are urgently needed. Our previous studies have demonstrated protective roles of… read more here.
Keywords: fasudil; adr induced; induced acute; senescence ... See more keywords
A ROCK1 Inhibitior Fasudil Alleviates Cardiomyocyte Apoptosis in Diabetic Cardiomyopathy by Inhibiting Mitochondrial Fission in a Type 2 Diabetes Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.892643
Abstract: Diabetes mellitus (DM) often involves cardiovascular complications; however, treatment regimens are limited. ROCK1 (rho-associated coiled-coil containing protein kinase 1) serves as a pathological factor in several diabetic complications. Herein, we aimed to explore the effect… read more here.
Keywords: apoptosis; fasudil; mitochondrial fission; rock1 ... See more keywords
Fasudil Increased the Sensitivity to Gefitinib in NSCLC by Decreasing Intracellular Lipid Accumulation
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DOI: 10.3390/cancers14194709
Abstract: Simple Summary The anti-tumor role of Fasudil in EGFR-mutation NSCLC as well as its mechanism are largely unknown. Here, we show that Fasudil could effectively inhibit EGFR-mutation cell growth and enhance the sensitivity of gefitinib-resistant… read more here.
Keywords: fasudil; gefitinib; intracellular lipid; lipid accumulation ... See more keywords