Morus alba L. water extract changes gut microbiota and fecal metabolome in mice induced by high‐fat and high‐sucrose diet plus low‐dose streptozotocin
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7343
Abstract: Gut microbiota plays a key role in the pathophysiology of type 2 diabetes mellitus (T2D). Mulberry leaf has a hypoglycemic effect, but the potential mechanism is not fully understood. This study aimed to explore the… read more here.
Keywords: water extract; gut microbiota; induced high; high fat ... See more keywords
Are Bisphosphonates Associated with Adverse Metabolic and Cognitive Effects? A Study in Intact Rats and Rats Fed High-Fat High-Fructose Diet
Sign Up to like & getrecommendations! Published in 2020 at "Calcified Tissue International"
DOI: 10.1007/s00223-020-00684-5
Abstract: Osteocalcin, known as a bone gla protein, is considered a regulator of energy metabolism and behavior in its undercarboxylated form (ucOC). Antiresorptive drugs, such as alendronate, reduce serum level of ucOC. The purpose of the… read more here.
Keywords: alendronate; fructose diet; group; fat high ... See more keywords
Beneficial effects of intermittent fasting on steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition"
DOI: 10.1016/j.nut.2019.02.020
Abstract: OBJECTIVE Intermittent fasting (IF) is a nutritional intervention with significant metabolic effects on the liver that are not yet fully understood. The aim of this study was to investigate the effects of IF on body… read more here.
Keywords: mice; fat high; beneficial effects; steatosis ... See more keywords
Morroniside Ameliorates High-Fat and High-Fructose-Driven Chronic Kidney Disease by Motivating AMPK-TFEB Signal Activation to Accelerate Lipophagy and Inhibiting Inflammatory Response.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c07684
Abstract: Studies have substantiated that dietary-fat- and fructose-overconsumption-caused lipid metabolism disorders can trigger renal lipotoxicity to drive the progression of chronic kidney disease (CKD). This study was conducted to evaluate the efficacy of morroniside, a natural… read more here.
Keywords: high fructose; morroniside; activation; ampk tfeb ... See more keywords
Fenofibrate Improves Cognitive Impairment Induced by High-Fat High-Fructose Diet: A Possible Role of Irisin and Heat Shock Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00186
Abstract: A high-fat, high-fructose diet (HFFD) impairs cognitive functions and increases susceptibility to neurodegenerative disorders. Irisin and heat shock protein 70 (HSP70) are well known for their role in neuroprotection. The possible neuroprotective effects of fenofibrate… read more here.
Keywords: irisin; hffd; high fructose; high fat ... See more keywords
Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study
Sign Up to like & getrecommendations! Published in 2025 at "Translational Psychiatry"
DOI: 10.1038/s41398-025-03701-z
Abstract: Maternal diet and metabolic conditions, such as obesity and diabetes, are associated with consequences for offspring brain health, including effects on behaviour and an increased risk for neurodevelopmental disorders (NDDs). The extent and sequence of… read more here.
Keywords: brain; brain development; development; high fat ... See more keywords
High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48973-w
Abstract: Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory–Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC)… read more here.
Keywords: phosphorylated inositol; kinase; hfc diet; high fat ... See more keywords
Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95117-0
Abstract: Although the mechanism of action of the antidiabetic drug metformin is still a matter of discussions, it is well accepted that the gut plays an important role. To gain more insights into the mechanisms occurring… read more here.
Keywords: hfs diet; high sucrose; fat high; high fat ... See more keywords
High-intensity interval training (HIIT) alleviated NAFLD feature via miR-122 induction in liver of high-fat high-fructose diet induced diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2018.1510968
Abstract: Abstract Background: Exercise intervention is strongly recommended to manage metabolic diseases. In this study, we investigate, whether HIIT and CET can induce hepatic miR-122 expression, NAFLD rats with diabetes. Methods: 40 Wistar rats divided into… read more here.
Keywords: hiit; fat high; high fat; mir 122 ... See more keywords
Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2166086
Abstract: Abstract Context α-Mangosteen (α-MG) attenuates insulin resistance (IR). However, it is still unknown whether α-MG could alleviate hepatic manifestations in IR rats. Objective To investigate the effect of α-MG on alleviating hepatic manifestations in IR… read more here.
Keywords: insulin resistance; hepatic manifestations; high fat; histopathology ... See more keywords
High-sugar, high-fat, and high-protein diets promote antibiotic resistance gene spreading in the mouse intestinal microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2021.2022442
Abstract: ABSTRACT Diet can not only provide nutrition for intestinal microbiota, it can also remodel them. However, is unclear whether and how diet affects the spread of antibiotic resistance genes (ARGs) in the intestinal microbiota. Therefore,… read more here.
Keywords: high sugar; intestinal microbiota; microbiota; sugar high ... See more keywords