Effect of a High‐Fat Meal on Single‐Dose Rencofilstat (CRV431) Oral Bioavailability in Healthy Human Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1179
Abstract: Rencofilstat (RCF) is a novel cyclophilin inhibitor under development for the treatment of nonalcoholic steatohepatitis and hepatocellular carcinoma. This phase 1, randomized, open‐label study in healthy participants assessed the relative bioavailability of a single dose… read more here.
Keywords: single dose; fat meal; high fat; bioavailability ... See more keywords
Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model‐informed Drug Development Strategy
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DOI: 10.1002/cpdd.1240
Abstract: Pexidartinib, an oral small molecule inhibitor of the colony‐stimulating factor 1 receptor, is approved for treatment of adults with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to… read more here.
Keywords: meal; low fat; dosing regimen; fat meal ... See more keywords
Postprandial dyslipidemia after a standardized high-fat meal in BMI-matched healthy individuals, and in subjects with prediabetes or type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2021.09.004
Abstract: BACKGROUND & AIMS A relationship between postprandial hyperlipidemia and glucose homeostasis/cardiovascular diseases has been suggested. We investigated postprandial plasma lipid patterns after a standardized high-fat meal and their association with glucose homeostasis and subclinical atherosclerosis.… read more here.
Keywords: fat meal; healthy individuals; meal; type diabetes ... See more keywords
Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status
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DOI: 10.1155/2018/5046508
Abstract: Background Frequently, ingestion of lipids exceeds our daily requirements and constantly exposes humans to circulating lipid overload which may lead to endothelial dysfunction (ED), the earliest marker of atherosclerosis. Nailfold videocapillaroscopy (NVC) technique can detect… read more here.
Keywords: min; rbcvmax trbcvmax; high fat; fat meal ... See more keywords
Determination of optimal cut-off points after a high-fat meal corresponding to fasting elevations of triglyceride and remnant cholesterol in Chinese subjects
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-1146-9
Abstract: BackgroundPostprandial high triglyceride (HTG), marking elevated level of remnant cholesterol (RC), is an independent risk factor of coronary heart disease (CHD). The postprandial cut-off points for HTG and high RC (HRC) after a daily meal… read more here.
Keywords: fat meal; meal; cut points; chinese subjects ... See more keywords
Pazopanib with low fat meal (PALM) in advanced renal cell carcinoma (RCC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.683
Abstract: 683Background: Pazopanib, a highly lipophilic standard first-line therapy for metastatic RCC, is conventionally taken in a fasting state but has significant gastrointestinal toxicities and 96% of ingested drug is fecally excreted, with major financial implications.… read more here.
Keywords: low fat; fat meal; pazopanib low; meal palm ... See more keywords
Pre-exercise meal on oxidation of energy substrates during maximal exercise test in non-trained individuals.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of endocrinology and metabolism"
DOI: 10.20945/2359-3997000000618
Abstract: Objective This study aimed to compare the influence of a high carbohydrate meal versus high-fat meal on the oxidation of substrates during an exercise incremental test. Materials and methods Ten untrained male subjects underwent two… read more here.
Keywords: oxidation; meal; test; fat meal ... See more keywords
Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults
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DOI: 10.3390/metabo12090853
Abstract: The purpose of the present study was to determine fasting and high-fat meal (HFM)-induced post-prandial systemic inflammation and airway inflammation (exhaled nitric oxide (eNO)) in older adults (OAs) compared to younger adults (YAs) before and… read more here.
Keywords: hfm; older adults; acute exercise; fat meal ... See more keywords