NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3590
Abstract: Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white… read more here.
Keywords: ppar; fat gene; fat specific; gene program ... See more keywords
Fat‐specific protein 27α inhibits autophagy‐dependent lipid droplet breakdown in white adipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13050
Abstract: Fat‐specific protein 27 (FSP27) α is the major isoform of FSP27 in white adipose tissue (WAT), and is essential for large unilocular lipid droplet (LD) formation in white adipocytes. In contrast, FSP27β is abundantly expressed… read more here.
Keywords: white adipocytes; fat specific; specific protein; lipid droplet ... See more keywords
NFIA Colocalizes with PPARgamma and Activates the Cell-Type–Specific Enhancers to Control the Brown Fat Gene Program
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-270-or
Abstract: Brown fat dissipates energy as heat by means of the uncoupling protein-1 (UCP1) on the mitochondrial inner membrane. Brown fat activity is inversely correlated with body mass index in humans, and pilot studies have shown… read more here.
Keywords: fat specific; ltd; novo nordisk; pharmaceutical ltd ... See more keywords