Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12569
Abstract: Mutations and ectopic FAT1 cadherin expression are implicated in a broad spectrum of diseases ranging from developmental disorders to cancer. The regulation of FAT1 and its downstream signalling pathways remain incompletely understood. We hypothesized that… read more here.
Keywords: regulator fat1; fat1; protein levels; fat1 protein ... See more keywords
Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13171
Abstract: The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of FAT1 in head and neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts… read more here.
Keywords: fat1 gene; hnscc; significance fat1; clinical significance ... See more keywords
FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31092
Abstract: Glioblastoma (GBM) is characterized by the presence of hypoxia, stemness and local invasiveness. We have earlier demonstrated that FAT1 promotes invasiveness, inflammation and upregulates HIF‐1α expression and its signaling in hypoxic GBM. Here, we have… read more here.
Keywords: stemness; emt stemness; fat1; expression ... See more keywords
Overexpression of the giant FAT1 cadherin gene and its prognostic significance in de novo acute leukaemia patients
Sign Up to like & getrecommendations! Published in 2017 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-017-2409-3
Abstract: FAT1 is a type 1 transmembrane protein belonging to the cadherin superfamily. Many reports showed either overexpression of FAT1 gene or its loss in solid cancers. Limited studies evaluated its importance in leukemogenesis. Real-time quantitative… read more here.
Keywords: adult aml; fat1; overexpression giant; leukaemia ... See more keywords
FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.197
Abstract: Fat1 cadherin is broadly expressed throughout the nervous system and has been implicated in neuronal differentiation. Here we examined the functional contribution of FAT1 during neuronal differentiation of the Ntera2 cell line model. FAT1 expression… read more here.
Keywords: ntera2 cell; fat1 cadherin; fat1; differentiation ... See more keywords
FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy107
Abstract: In recent years, the incidence and mortality rates of head and neck squamous cell carcinoma (HNSCC) have increased worldwide. Therefore, understanding genomic alterations in HNSCC carcinogenesis is crucial for appropriate diagnosis and therapy. Protocadherin FAT1,… read more here.
Keywords: fat1 somatic; fat1; expression; fat1 mutations ... See more keywords
PATH-65. MOLECULAR SIGNATURE OF FAT1 RELATED MOLECULES IN GLIOMAS IN THE CONTEXT OF THE WHO 2016 CLASSIFICATION
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.660
Abstract: Glioblastoma (GBM, WHO grade-IV) being the most malignant and aggressive form of glioma remains a major clinical challenge, with an overall 5-year survival rate of only 9.8%. Till recently, glioma diagnosis and grading were solely… read more here.
Keywords: glioma; molecular signature; fat1 related; fat1 ... See more keywords
PO-125 FAT1 on salvador-warts-hippo (SWH) pathway in human glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.166
Abstract: Introduction Glioblastoma(GBM) is an aggressive brain tumour arising from glial cells. Our lab has identified the oncogenic role of FAT1 gene in GBM, regulating inflammatory and hypoxic microenvironment of the tumour as well as migratory/invasive… read more here.
Keywords: yap1; fat1; tead1; salvador warts ... See more keywords
Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism.
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DOI: 10.1242/bio.056457
Abstract: Genetic studies have linked FAT1 (FAT atypical cadherin 1) with autism spectrum disorder (ASD), however, the role that FAT1 plays in ASD remains unknown. In mice, the function of Fat1 has been primarily implicated in… read more here.
Keywords: atypical cadherin; autism; fat1; expression ... See more keywords
Upregulation of Atypical Cadherin FAT1 Promotes an Immunosuppressive Tumor Microenvironment via TGF-β
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.813888
Abstract: FAT atypical cadherin 1 (FAT1) promotes glioblastoma (GBM) by promoting protumorigenic inflammatory cytokine expression in tumor cells. However, tumors also have an immunosuppressive microenvironment maintained by mediators such as transforming growth factor (TGF)-β cytokines. Here,… read more here.
Keywords: microenvironment; tumor; fat1; expression ... See more keywords