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   Articles with "fat10" as a keyword



Human leukocyte antigen F-associated transcript 10 regulates the IKs potassium channel by competing for Kv7.1 ubiquitination

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recommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"

DOI: 10.1098/rstb.2022.0167

Abstract: The protein expression and function changes from the slow-delayed rectifying K+ current, IKs, are tightly associated with ventricular cardiac arrhythmias. Human leukocyte antigen F-associated transcript 10 (FAT10), a member of the ubiquitin-like-modifier family, exerts a… read more here.

Keywords: antigen associated; iks; fat10; kv7 ubiquitination ... See more keywords

FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly

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recommendations! Published in 2020 at "Journal of Cell Science"

DOI: 10.1242/jcs.240085

Abstract: ABSTRACT Dendritic cell (DC) aggresome-like induced structures (DALIS) are protein aggregates of polyubiquitylated proteins that form transiently during DC maturation. DALIS scatter randomly throughout the cytosol and serve as antigen storage sites synchronising DC maturation… read more here.

Keywords: aggresome like; dalis; cell aggresome; fat10 ... See more keywords

The ubiquitin-like modifier FAT10 is not essential for MHC-I antigen presentation

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1636951

Abstract: Introduction The presentation of pathogen-derived antigens on major histocompatibility complex (MHC) class I is crucial for the antiviral immune response. Degradation of intracellular pathogen-derived proteins by the 26S proteasome generates peptides that can be loaded… read more here.

Keywords: antigen presentation; fat10; ubiquitin like; mhc ... See more keywords

Ubiquitin like protein FAT10 repressed cardiac fibrosis after myocardial ischemic via mediating degradation of Smad3 dependent on FAT10-proteasome system

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recommendations! Published in 2023 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.77677

Abstract: Cardiac fibrosis after myocardial ischemic (MI) injury is a key factor in heart function deterioration. We recently showed that ubiquitin-like protein human HLA-F adjacent transcript (FAT10) plays a novel role in ischemic cardiovascular diseases, but… read more here.

Keywords: cardiac fibrosis; fat10; degradation; fibrosis ... See more keywords

FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells

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recommendations! Published in 2023 at "International Journal of Medical Sciences"

DOI: 10.7150/ijms.77367

Abstract: Background and objectives: Hepatic stellate cell (HSC) activation is the cardinal factor due to the accumulation of extracellular matrix proteins during the development of liver fibrosis. The aim of the present study was to find… read more here.

Keywords: hepatic stellate; fat10; liver fibrosis; expression ... See more keywords