Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.05.007
Abstract: T cells undergo metabolic reprogramming with major changes in cellular energy metabolism during activation. In patients with mitochondrial disease, clinical data were marked by frequent infections and immunodeficiency, prompting us to explore the consequences of… read more here.
Keywords: cytochrome oxidase; fate decisions; cell activation; cell fate ... See more keywords
Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102471
Abstract: Summary Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization is considered… read more here.
Keywords: cytokine; cytokine receptors; fate decisions; synthetic cytokine ... See more keywords
Systems analysis reveals complex biological processes during virus infection fate decisions.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.241372.118
Abstract: The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune response and chronic… read more here.
Keywords: response; fate decisions; infection; infection fate ... See more keywords
mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions
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DOI: 10.1111/imr.12845
Abstract: The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates signals from the environment to coordinate downstream signaling events and various cellular processes. T cells… read more here.
Keywords: fate decisions; mtor signaling; mtor; cell fate ... See more keywords
Cell fate decisions during development
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aax7917
Abstract: Cell differentiation involves activation of mutually exclusive genetic programs The shape of our nose, the color of our skin, the movement of our gut, all depend on an extraordinary cell type called neural crest cells,… read more here.
Keywords: fate decisions; cell fate; neural crest; crest cells ... See more keywords
Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022018564
Abstract: Hematopoietic stem cells (HSCs) are assumed to be rare, infrequently dividing, long-lived, and not involved in immediate recovery after transplantation. Here we performed unprecedented high-density clonal tracking in nonhuman primates and found long-term persisting HSC… read more here.
Keywords: fate decisions; contribution; stochastic fate; transplantation ... See more keywords
Control of T lymphocyte fate decisions by PI3K signaling
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.26928.1
Abstract: Virtually all aspects of T and B lymphocyte development, homeostasis, activation, and effector function are impacted by the interaction of their clonally distributed antigen receptors with antigens encountered in their respective environments. Antigen receptors mediate… read more here.
Keywords: signaling pathways; control lymphocyte; fate decisions; decisions pi3k ... See more keywords
Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory
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DOI: 10.3390/cancers9070070
Abstract: Waddington’s epigenetic landscape, a famous metaphor in developmental biology, depicts how a stem cell progresses from an undifferentiated phenotype to a differentiated one. The concept of “landscape” in the context of dynamical systems theory represents… read more here.
Keywords: fate decisions; phenotypic plasticity; cell fate; dynamical systems ... See more keywords
Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030612
Abstract: Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of chicken PGCs in terms of their development, integrity, and sex determination have unique features, thereby providing insights into evolutionary developmental… read more here.
Keywords: fate decisions; development; decisions chicken; cells pgcs ... See more keywords