A method for the quantitative determination of glycerophospholipid regioisomers by UPLC-ESI-MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1517-5
Abstract: Diacyl glycerophospholipids (GPs) belong to the most abundant lipid species in living organisms and consist of a glycerol backbone with fatty acyl groups in sn-1 and sn-2 and a polar head group in the sn-3… read more here.
Keywords: diacyl; mixed diacyl; method quantitative; method ... See more keywords
Identification of adaptive inhibitors of Cryptosporidium parvum fatty acyl-coenzyme A synthetase isoforms by virtual screening
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06445-0
Abstract: Cryptosporidiosis is a significant cause of gastroenteritis in both humans and livestock in developing countries. The only FDA-approved drug available against the same is nitazoxanide, with questionable efficacy in malnourished children and immunocompromised patients. Recent… read more here.
Keywords: virtual screening; cryptosporidium parvum; acyl coenzyme; coenzyme synthetase ... See more keywords
A New N-Fatty Acyl Tryptamine from Annana atemoya
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-020-03235-4
Abstract: A new N-fatty acyl tryptamine, N-nonadecanoyl-4,5-dihydroxytryptamine (1), was isolated from the stems of Annona atemoya. The structure of the new tryptamine-derived amide was elucidated by chemical and physical evidence. read more here.
Keywords: fatty acyl; annana atemoya; acyl tryptamine; new fatty ... See more keywords
Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium(IV) Oxide.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b00894
Abstract: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a powerful technique for spatially resolved metabolomics. A variation on MALDI, termed metal oxide laser ionization (MOLI), capitalizes on the unique property of cerium(IV) oxide (CeO2)… read more here.
Keywords: mass spectrometry; msi; ionization mass; moli msi ... See more keywords
Effect of Hydrophobicity on the Anticancer Activity of Fatty-Acyl-Conjugated CM4 in Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02093
Abstract: Antimicrobial peptides (AMPs) are important anticancer resources, and exploring AMP conjugates as highly effective and selective anticancer agents would represent new progress in cancer treatment. In this study, we synthesized C4–C16 fatty-acyl-conjugated AMP CM4 and… read more here.
Keywords: acyl; breast cancer; cm4; fatty acyl ... See more keywords
Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47709-0
Abstract: The long-chain (≥C20) polyunsaturated fatty acid biosynthesis capacity of fish varies among species, with trophic level hypothesised as a major factor. The biosynthesis capacity is largely dependent upon the presence of functionally diversified fatty acyl… read more here.
Keywords: trophic level; diversification teleost; teleost fads2; fads2 ... See more keywords
Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2022050119
Abstract: Significance Protein palmitoylation is one of the most highly abundant protein modifications, through which long-chain fatty acids get attached to cysteines by a thioester linkage. It plays critically important roles in growth signaling, the organization… read more here.
Keywords: integral membrane; chemistry; palmitoyl coa; coa ... See more keywords
Ribosomally derived lipopeptides containing distinct fatty acyl moieties
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113120119
Abstract: Significance Fatty-acylated lipopeptides are metabolites of high medical and biotechnological importance, exemplified by the clinically used daptomycin, polymyxin, and echinocandin anti-infectives. The known representatives are produced by giant nonribosomal enzymes that usually generate heterogeneously acylated… read more here.
Keywords: fatty acylated; distinct fatty; acyl moieties; fatty acyl ... See more keywords
Fatty acyl recognition and transfer by an integral membrane S-acyltransferase
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aao6326
Abstract: Fattening up proteins Many eukaryotic proteins are modified by the attachment of lipids, and these modifications can alter how proteins interact with cellular membranes. Rana et al. present x-ray crystal structures of an integral membrane… read more here.
Keywords: chain; fatty acyl; dhhc; membrane ... See more keywords
An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.223016
Abstract: ABSTRACT Fatty acyl-CoA reductase 1 (Far1) is a ubiquitously expressed peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids. Lipid droplet localization of exogenously expressed and endogenous human Far1… read more here.
Keywords: microscopy; acyl coa; topology; fatty acyl ... See more keywords
Accumulation of medium-chain, saturated fatty acyl moieties in seed oils of transgenic Camelina sativa
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0172296
Abstract: With its high seed oil content, the mustard family plant Camelina sativa has gained attention as a potential biofuel source. As a bioenergy crop, camelina has many advantages. It grows on marginal land with low… read more here.
Keywords: chain; seed; camelina; seed oils ... See more keywords