Sensitive and Selective Bioscreening of the Most Commonly Used Coronavirus Disease Drug, Favipiravir, and Its Co-Administered therapeutic, Meropenem, in Human Plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200332
Abstract: Favipiravir and Meropenem have been concurrently used as directly acting antiviral and antibiotic agents for the treatment of coronavirus disease in human plasma. Accurate and specific reversed phase ultra-performance liquid chromatographic and high performance thin… read more here.
Keywords: human plasma; coronavirus disease; meropenem; favipiravir ... See more keywords
Real‐time monitoring of enzyme‐catalyzed phosphoribosylation of anti‐influenza prodrug favipiravir by time‐lapse nuclear magnetic resonance spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4888
Abstract: Favipiravir (brand name Avigan), a widely known anti‐influenza prodrug, is metabolized by endogenous enzymes of host cells to generate the active form, which exerts inhibition of viral RNA‐dependent RNA polymerase activity; first, favipiravir is converted… read more here.
Keywords: time; anti influenza; influenza prodrug; spectroscopy ... See more keywords
Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial
Sign Up to like & getrecommendations! Published in 2021 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-021-00517-4
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded RNA virus. Favipiravir is an orally administrable antiviral drug whose mechanism of action is to selectively inhibit… read more here.
Keywords: oxygen; trial; favipiravir; covid ... See more keywords
Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104758
Abstract: BACKGROUND In spite of recurrent and dramatic outbreaks, there are no therapeutics approved against Ebola virus disease. Favipiravir, a RNA polymerase inhibitor active against several RNA viruses, recently demonstrated significant but not complete protection in… read more here.
Keywords: non human; ebola virus; model; bid ... See more keywords
Novel environment friendly TLC-densitometric method for the determination of anti-coronavirus drugs “Remdesivir and Favipiravir”: Green assessment with application to pharmaceutical formulations and human plasma
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.107101
Abstract: A great demand for discovering new therapeutic solutions has been considered all over the world for managing the rapidly progressing COVID-19 pandemic. Remdesivir (REM) and Favipiravir (FAV) are introduced as promising newly developed antiviral agents… read more here.
Keywords: pharmaceutical formulations; method; human plasma; densitometric method ... See more keywords
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2118398
Abstract: Abstract Favipiravir, an RNA-dependent RNA polymerase (RdRp) inhibitor, is used to treat patients infected with influenza virus and most recently with SARS-CoV-2. However, poor accumulation of favipiravir in lung tissue following oral administration has required… read more here.
Keywords: time; stability; solution; favipiravir ... See more keywords
US201 Study: A Phase 2, Randomized Proof-of-Concept Trial of Favipiravir for the Treatment of COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofab563
Abstract: Abstract Background Favipiravir is used to treat influenza, and studies demonstrate that it has antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We performed a randomized, open-label, multicenter, phase 2 proof-of-concept trial… read more here.
Keywords: group; day; disease; favipiravir ... See more keywords
Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01217-18
Abstract: New antiviral drugs are needed as a first line of defense in the event of a novel influenza pandemic. Favipiravir is a broad-spectrum antiviral which is effective against influenza. The exact mechanism of how favipiravir… read more here.
Keywords: mutation bias; influenza; bias; next generation ... See more keywords
22 Favipiravir pharmacokinetics in immunocompromised infants and children with chronic RNA viral infections
Sign Up to like & getrecommendations! Published in 2023 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2023-esdppp.22
Abstract: Introduction Favipiravir selectively inhibits RNA polymerase responsible for single-stranded viral replication. It is licensed for treating influenza and repurposed to treat other diseases such as Ebola and COVID-19. It is metabolised by hepatic aldehyde oxidase… read more here.
Keywords: immunocompromised infants; pharmacokinetics immunocompromised; favipiravir pharmacokinetics; model ... See more keywords
A favipiravir-induced angioedema and urticaria in a COVID-19 patient
Sign Up to like & getrecommendations! Published in 2022 at "Antiviral Therapy"
DOI: 10.1177/13596535221146226
Abstract: Although favipiravir is a promising drug for coronavirus disease 2019, some adverse effects, including skin lesions, have been reported. A 56-year-old female who was prescribed favipiravir by a filiation team following a positive severe acute… read more here.
Keywords: angioedema urticaria; induced angioedema; urticaria covid; favipiravir induced ... See more keywords
Advancements in Antiviral Therapy: Favipiravir Sodium in Nasal Formulation
Sign Up to like & getrecommendations! Published in 2024 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-024-02986-5
Abstract: Favipiravir (FPV) is an Active Pharmaceutical Ingredient (API) known to have lower solubility in aqueous solvents. In the current study, efforts were made to generate a crystalline Favipiravir Sodium Salt (NaFPV) for enhanced solubility in… read more here.
Keywords: solubility; favipiravir; favipiravir sodium; nafpv showed ... See more keywords