Disordered linkers in multidomain allosteric proteins: Entropic effect to favor the open state or enhanced local concentration to favor the closed state?
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3475
Abstract: There are many multidomain allosteric proteins where an allosteric signal at the allosteric domain modifies the activity of the functional domain. Intrinsically disordered regions (linkers) are widely involved in this kind of regulation process, but… read more here.
Keywords: state; allosteric proteins; favor; multidomain allosteric ... See more keywords
Extended anticoagulation in venous thromboembolism disease. In favor
Sign Up to like & getrecommendations! Published in 2017 at "Revista Clinica Espanola"
DOI: 10.1016/j.rceng.2017.04.003
Abstract: Abstract Venous thromboembolism disease can be considered a chronic disease because, after the first episode, there is a life-long risk of recurrence. Recurrence is a severe complication. Anticoagulation is effective while it is maintained, but… read more here.
Keywords: anticoagulation; favor; thromboembolism disease; disease ... See more keywords