Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics.
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DOI: 10.1021/acsmedchemlett.5c00521
Abstract: While investigating the SAR associated with tasquinimod, whose anticancer activity is primarily derived from inhibition of S100A9 and HDAC4, we designed and prepared several analogues. We identified a potent hit (FB2) that showed cytotoxicity against… read more here.
Keywords: microtubule dynamics; fb2; mitotic arrest; tasquinimod ... See more keywords