Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200546
Abstract: Extracellular matrix (ECM) remodeling is crucial in the regulation of gastric cancer (GC) progression. This work aims to reveal novel posttranslational modifications and their relevant mechanisms in GC. In 3D matrix culture and animal models,… read more here.
Keywords: extracellular matrix; fbn1; succinylation; progression ... See more keywords
CRISPR/Cas9 in zebrafish: An attractive model for FBN1 genetic defects in humans.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular genetics & genomic medicine"
DOI: 10.1002/mgg3.1775
Abstract: BACKGROUND Mutations in the fibrillin-1 gene (FBN1) are associated with various heritable connective tissue disorders (HCTD). The most studied HCTD is Marfan syndrome. Ninety percent of Marfan syndrome is caused by mutations in the FBN1… read more here.
Keywords: fbn1; crispr cas9; fbn1 zebrafish; model ... See more keywords
A potential role of fibrillin-1 (FBN1) mRNA and asprosin in follicular development in water buffalo.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.11.004
Abstract: Fibrillin-1 (FBN1) functions as a structural protein in the ovary, while the role of its protein product asprosin remains unknown. Both proteins are encoded by the FBN1 gene and when it is cleaved at the… read more here.
Keywords: fbn1; asprosin; water buffalo; asprosin follicular ... See more keywords
Affected-embryo-based SNP haplotyping with NGS for the preimplantation genetic testing of Marfan syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2021.1926574
Abstract: ABSTRACT Marfan syndrome (MFS), an autosomal dominant heritable disease of the connective tissue, is characterized by broad clinical manifestations in the musculoskeletal, cardiovascular, pulmonary, and ocular systems. In this study, a male patient with MFS… read more here.
Keywords: fbn1; genetic testing; snp haplotyping; marfan syndrome ... See more keywords
PSIV-5 Developmental and hormonal regulation of gene expression of fibrillin-1 (FBN1) and the asprosin receptor, olfactory receptor family 4 subfamily M member 1 (OR4M1), in bovine ovarian cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Animal Science"
DOI: 10.1093/jas/skaa278.510
Abstract: Asprosin is a novel fasting-induced protein associated with insulin resistance and polycystic ovaries in humans. It is encoded by FBN1 gene and produced when FBN1 is cleaved by the enzyme furin. In cattle, the role… read more here.
Keywords: receptor; fbn1; mrna abundance; fbn1 mrna ... See more keywords
New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis
Sign Up to like & getrecommendations! Published in 2019 at "SPINE"
DOI: 10.1097/brs.0000000000002809
Abstract: Study Design. A genetic association study. Objective. To determine whether common variants of fibrillin-1 (FBN1) and fibrillin-2 (FBN2) are associated with adolescent idiopathic scoliosis (AIS), and to further investigate to further investigate the functional role… read more here.
Keywords: expression; idiopathic scoliosis; role; fbn1 ... See more keywords
Identification of a novel pathogenic variant in FBN1 associated with Marfan syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a006215
Abstract: Aortic diseases arising in Marfan syndrome (MFS), such as in aneurysms and dissections of the thoracic aorta, are related to genetic alterations in the FBN1 gene. Databases, such as Universal Mutations-FBN1, ClinVar, and The Human… read more here.
Keywords: fbn1; fbn1 gene; marfan syndrome; variant ... See more keywords
Assembly assay identifies a critical region of human fibrillin-1 required for 10–12 nm diameter microfibril biogenesis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0248532
Abstract: The human FBN1 gene encodes fibrillin-1 (FBN1); the main component of the 10–12 nm diameter extracellular matrix microfibrils. Marfan syndrome (MFS) is a common inherited connective tissue disorder, caused by FBN1 mutations. It features a… read more here.
Keywords: microfibril; fbn1; assembly; microfibril biogenesis ... See more keywords