FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.02.011
Abstract: Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical interaction between FBXL5 and IRP2 is regulated remains elusive.… read more here.
Keywords: fbxl5; oxygen; iron homeostasis; iron ... See more keywords
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
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DOI: 10.1038/ncomms16114
Abstract: Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation… read more here.
Keywords: fbxl5; hscs; hematopoietic stem; iron ... See more keywords
FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells
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DOI: 10.1128/mcb.00470-16
Abstract: ABSTRACT FBXL5 is the substrate recognition subunit of an SCF-type ubiquitin ligase that serves as a master regulator of iron metabolism in mammalian cells. We previously showed that mice with systemic deficiency of FBXL5 fail… read more here.
Keywords: fbxl5; progenitor cells; stem progenitor; iron ... See more keywords