FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-00362-7
Abstract: Myelodysplastic syndrome (MDS) is a heterogeneous myeloid malignancy characterized by blood cell morphological dysplasia, ineffective clonal hematopoiesis, and risk of transformation to secondary acute myeloid leukemia (sAML). A number of genetic abnormalities have been identified… read more here.
Keywords: tumor suppressor; myelodysplastic syndrome; fbxo11; transformation ... See more keywords
The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6
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DOI: 10.1128/jvi.00548-24
Abstract: ABSTRACT Most mature B-cell malignancies originate from the malignant transformation of germinal center (GC) B cells. The GC reaction appears to have a role in malignant transformation, in which a major player of the GC… read more here.
Keywords: reaction; protein; cell; fbxo11 ... See more keywords
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins
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DOI: 10.26508/lsa.202201735
Abstract: FBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins. Staphylococcus aureus causes severe infections such as pneumonia and sepsis depending on… read more here.
Keywords: c5ar1; inflammation; fbxo11; expression ... See more keywords