E3 ubiquitin ligase FBXO22 inhibits SARS‐CoV‐2 replication via promoting proteasome‐dependent degradation of NSP5
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29891
Abstract: The ubiquitin‐proteasome system is frequently employed to degrade viral proteins, thereby inhibiting viral replication and pathogenicity. Through an analysis of the degradation kinetics of all the SARS‐CoV‐2 proteins, our study revealed rapid degradation of several… read more here.
Keywords: sars cov; replication; degradation; degradation nsp5 ... See more keywords
Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway
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DOI: 10.1007/s10637-019-00761-z
Abstract: F-box proteins, a type of substrate-recognition complexes consisting of SKP1-cullin 1-F-box protein (SCF) E3 ligase, can critically affect many cellular processes because of the ubiquitylation and subsequent degradation of target proteins. This study investigated the… read more here.
Keywords: migration invasion; hif; angiogenesis; fbxo22 ... See more keywords
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00827-7
Abstract: SKP1-CUL1-F-box (SCF) ubiquitin ligases play fundamental roles in cellular functions. Typically, substrate phosphorylation is required for SCF recognition and subsequent degradation. However, phospho-dependent substrates remain largely unidentified. Here, using quantitative phoshoproteome approach, we performed a… read more here.
Keywords: bag3; scf substrates; phospho dependent; fbxo22 ... See more keywords
Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22
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DOI: 10.3389/fonc.2021.790912
Abstract: The F-box protein 22 (FBXO22), an F-box E3 ligase, has been identified to be critically involved in carcinogenesis. However, a systematic assessment of the role of FBXO22 across human cancers is lacking. Here, we performed… read more here.
Keywords: cell; box protein; role; fbxo22 ... See more keywords
FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2025.5707
Abstract: Macrophages play a key role in hepatocellular carcinoma (HCC) progression, but the mechanisms underlying this involvement remain unclear. In the present study, mice with HCC were used for in vivo experiments, and 97H and THP-1… read more here.
Keywords: progression; 97h cells; myo inositol; fbxo22 ... See more keywords