The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway
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DOI: 10.1038/s41420-022-00868-y
Abstract: F-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain, resulting in ubiquitination. Ubiquitination and the subsequent degradation of… read more here.
Keywords: hippo pathway; fbxw5; gastric cancer; cohort ... See more keywords
FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway
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DOI: 10.3390/cancers11060836
Abstract: F-box/WD repeat-containing protein 5 (FBXW5) is a member of the FBXW subclass of F-box proteins. Despite its known function as a component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, the role of FBXW5 in gastric… read more here.
Keywords: tumorigenesis metastasis; gastric cancer; cancer; fbxw5 ... See more keywords