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   Articles with "fbxw7" as a keyword



FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12200

Abstract: Gefitinib, an epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR‐TKI), is an effective treatment for non‐small‐cell lung cancer (NSCLC) with EGFR activating mutations, but inevitably, the clinical efficacy is impeded by the emergence of acquired resistance.… read more here.

Keywords: tumor development; gefitinib; lung tumor; therapy ... See more keywords
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Honokiol antagonizes doxorubicin resistance in human breast cancer via miR-188-5p/FBXW7/c-Myc pathway

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recommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"

DOI: 10.1007/s00280-021-04238-w

Abstract: Honokiol, a natural phenolic compound derived from Magnolia plants, is a promising anti-tumor compound that exerts a wide range of anti-cancer effects. Herein, we investigated the effect of honokiol on doxorubicin resistance in breast cancer.… read more here.

Keywords: breast cancer; honokiol; cancer; fbxw7 ... See more keywords

Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.

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recommendations! Published in 2022 at "American journal of human genetics"

DOI: 10.1016/j.ajhg.2022.03.002

Abstract: Neurodevelopmental disorders are highly heterogenous conditions resulting from abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain-containing 7), a recognized developmental regulator and tumor suppressor, has been shown to regulate cell-cycle progression and cell… read more here.

Keywords: neurodevelopmental syndrome; fbxw7; tumor suppressor; syndrome ... See more keywords

E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat

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recommendations! Published in 2025 at "EMBO Reports"

DOI: 10.1038/s44319-024-00337-w

Abstract: Thermogenic fat, including brown and beige fat, dissipates heat via thermogenesis and enhances energy expenditure. Thus, its activation represents a therapeutic strategy to combat obesity. Here, we demonstrate that levels of F-box and WD repeat… read more here.

Keywords: fbxw7 depletion; fat expansion; brown fat; fat ... See more keywords

Astragalus polysaccharides inhibit ovarian cancer cell growth via microRNA-27a/FBXW7 signaling pathway

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recommendations! Published in 2020 at "Bioscience Reports"

DOI: 10.1042/bsr20193396

Abstract: Abstract Astragalus polysaccharide (APS), a natural antioxidant found in Astragalus membranaceus emerging as a novel anticancer agent, exerts antiproliferative and pro-apoptotic activity in various cancer cell types, but its effect on ovarian cancer (OC) remains… read more here.

Keywords: ovarian cancer; cell growth; fbxw7; cancer cell ... See more keywords

The FBXW7–KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanism

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2423130122

Abstract: Significance While F-box and WD repeat domain-containing 7 (FBXW7) is a typical tumor suppressor, frequently inactivated in human cancers, it is unknown whether FBXW7 also acts as a tumor suppressor via targeting cancer-associated fibroblasts (CAFs)… read more here.

Keywords: paracrine mechanism; fbxw7; tumor; associated fibroblasts ... See more keywords

FBXW7 modulates malignant potential and cisplatin‐induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1

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recommendations! Published in 2018 at "Cancer Science"

DOI: 10.1111/cas.13829

Abstract: The ubiquitin ligase F‐box and WD repeat domain‐containing 7 (FBXW7) is responsible for degrading diverse oncoproteins and is considered a tumor suppressor in many human cancers. Inhibiting FBXW7 enhances the malignant potential of several cancers.… read more here.

Keywords: modulates malignant; cholangiocarcinoma; fbxw7 modulates; notch1 mcl1 ... See more keywords

Exosomal miR‐106a‐5p accelerates the progression of nasopharyngeal carcinoma through FBXW7‐mediated TRIM24 degradation

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recommendations! Published in 2022 at "Cancer Science"

DOI: 10.1111/cas.15337

Abstract: Nasopharyngeal carcinoma (NPC) is prevalent in East Asia and causes increased health burden. Elucidating the regulatory mechanism of NPC progression is important for understanding the pathogenesis of NPC and developing novel therapeutic strategies. Nasopharyngeal carcinoma… read more here.

Keywords: nasopharyngeal carcinoma; fbxw7; mir 106a; exosomal mir ... See more keywords

The HTLV-I oncoprotein Tax inactivates the tumor suppressor FBXW7

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recommendations! Published in 2024 at "Journal of Virology"

DOI: 10.1128/jvi.00405-24

Abstract: ABSTRACT Human T-cell leukemia virus type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL). Mutational analysis has demonstrated that the tumor suppressor, F-box and WD repeat domain containing 7 (FBXW7/FBW7/CDC4), is mutated… read more here.

Keywords: fbxw7; oncoprotein tax; tax; tumor suppressor ... See more keywords

Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7

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recommendations! Published in 2022 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/annrheumdis-2021-221513

Abstract: Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression. Methods F-box and WD repeat domain containing 7 (FBXW7) ubiquitin ligase expression and chondrocyte senescence… read more here.

Keywords: cartilage; osteoarthritis; fbxw7; mechanical overloading ... See more keywords

Abstract LT10: Recurrent FBXW7 Mutations Bypass Wnt/β-catenin Addiction in Cancer

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.fcs2023-lt10

Abstract: Inactivating mutations in RNF43 or gene fusions involving RSPO2/3 are potent activators of ligand-dependent Wnt signaling and drive multiple human cancers. Pharmacologically targeting the biogenesis of Wnt ligands, e.g., with PORCN inhibitors, is being investigated… read more here.

Keywords: fbxw7; cancer; wnt catenin; fbxw7 mutations ... See more keywords