Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.
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DOI: 10.1016/j.molcel.2017.03.013
Abstract: MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions, DROSHA serves as a main determinant of miRNA sequences and a highly selective… read more here.
Keywords: mirna; drosha cleavage; fclip; cleavage sites ... See more keywords