LAUSR

Engineered FcRn Binding Fusion Peptides Significantly Enhance the Half-Life of a Fab Domain in Cynomolgus Monkeys.

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2 Published in 2019 at "Biotechnology journal"

DOI: 10.1002/biot.201800007

Abstract: There is a rapidly growing reinvigoration of the investigation of small proteins, cyclic peptides, and mAb derived domains as biotherapies. The drugability of these structures are challenged by fast peripheral clearance properties that can reduce… read more here.

Keywords: fcrn binding; cynomolgus monkeys; fab; fusion ... See more keywords

Human serum albumin presents isoform variants with altered neonatal Fc receptor interactions

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0 Published in 2019 at "Protein Science"

DOI: 10.1002/pro.3733

Abstract: Human serum albumin (HSA) is the most abundant protein in plasma and presents the particularity, with IgG, to have an extraordinary long serum half‐life conferred by its interaction with the neonatal Fc receptor (FcRn). If… read more here.

Keywords: fcrn binding; hsa; human serum; neonatal receptor ... See more keywords

Short FcRn-Binding Peptides Enable Salvage and Transcytosis of scFv Antibody Fragments.

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3 Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.1c00862

Abstract: Therapeutic antibodies have become one of the most widely used classes of biotherapeutics due to their unique antigen specificity and their ability to be engineered against diverse disease targets. There is significant interest in utilizing… read more here.

Keywords: size; fcrn; short fcrn; fcrn binding ... See more keywords

Consideration of C1q and FcRn binding to allotypically disparate IgG3 could aid in engineering more efficacious anti-SARS-CoV-2 mAbs

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2 Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2306078120

Abstract: Izadi et al. (1) have added to the increasing body of evidence that IgG3 monoclonal antibodies (mAbs) are more potent than their IgG1 counterparts in mediating Fc-mediated effector functions. They also show that immunoglobulin constant… read more here.

Keywords: fcrn binding; immunology; half life; fcrn ... See more keywords