Model-Based Assessment of the Contribution of Monocytes and Macrophages to the Pharmacokinetics of Monoclonal Antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical research"
DOI: 10.1007/s11095-022-03177-2
Abstract: PURPOSE We have hypothesized that a high concentration of circulating monocytes and macrophages may contribute to the fast weight-based clearance of monoclonal antibodies (mAbs) in young children. Exploring this hypothesis, this work uses modeling to… read more here.
Keywords: model based; circulating monocytes; monocytes macrophages; based assessment ... See more keywords
Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.03085
Abstract: Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered… read more here.
Keywords: transmissible gastroenteritis; gastroenteritis virus; tgev; fcrn expression ... See more keywords