Jumping from Fragment to Drug via Smart Scaffolds
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200092
Abstract: A focused drug repurposing approach is described where an FDA‐approved drug is rationally selected for biological testing based on structural similarities to a fragment compound found to bind a target protein by an NMR screen.… read more here.
Keywords: smart scaffolds; fda approved; drug; fragment drug ... See more keywords
Repurposing of FDA-approved drugs as inhibitors of sterol C-24 methyltransferase of Leishmania donovani to fight against leishmaniasis.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21820
Abstract: Leishmaniasis is a vector-borne disease caused by around 20 species of Leishmania. The main clinical forms of leishmaniasis are cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). VL is caused by Leishmania infantum in Central and… read more here.
Keywords: sterol methyltransferase; leishmaniasis; drug; donovani ... See more keywords
Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21953
Abstract: The salification and prodrug approaches modulate the physicochemical properties and absorption, distribution, metabolism, excretion, and toxicity parameters of drugs and lead candidates. The “phosphate” is one of the key counterions/promoiety used in the salt formation… read more here.
Keywords: phosphate; phosphate moiety; salts prodrugs; phosphate salts ... See more keywords
Strategic Utilization of Next‐Generation Deep Brain Stimulation Pulse Generators
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13689
Abstract: Deep brain stimulation (DBS) is a well-established treatment for movement disorders. Recent industrial competition has led to unprecedented new technologic implementation. Nextgeneration implantable pulse generators (IPGs), henceforth defined as FDA-approved devices after 2015, include Abbott… read more here.
Keywords: boston; dbs; boston scientific; next generation ... See more keywords
Objective Comparison of FDA-Approved Breast Implant Products in the USA: 5-Year Update
Sign Up to like & getrecommendations! Published in 2021 at "Aesthetic Plastic Surgery"
DOI: 10.1007/s00266-021-02395-0
Abstract: There are currently four companies offering FDA-approved breast implants: Allergan, Sientra, Mentor, and Ideal Implant. In 2015, our paper “Objective Comparison of Commercially Available Breast Implant Devices” sought to provide a unique conceptual framework to… read more here.
Keywords: breast implant; breast; objective comparison; company ... See more keywords
Surveying FDA-approved drugs as new potential inhibitors of N-cadherin protein: a virtual screening approach
Sign Up to like & getrecommendations! Published in 2020 at "Structural Chemistry"
DOI: 10.1007/s11224-020-01595-9
Abstract: Since N-cadherin protein plays a remarkable role in cancer metastasis and tumor growth and progression, finding new effective inhibitors of this protein can be of high importance in cancer treatment. Nevertheless, few molecules have been… read more here.
Keywords: potential inhibitors; surveying fda; inhibitors cadherin; cadherin protein ... See more keywords
Reporting of Drug Benefit in FDA-Approved Prescription Drug Labeling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-019-05460-2
Abstract: Obtaining an accurate understanding of the known benefits and risks of drugs is difficult, particularly when drugs first come to market. The most robust evidence is largely limited to pre-marketing studies (e.g., phase 3 trials),… read more here.
Keywords: reporting drug; benefit; information; drug ... See more keywords
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2020.104787
Abstract: Abstract Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown… read more here.
Keywords: ivermectin inhibits; drug ivermectin; approved drug; ivermectin ... See more keywords
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.108959
Abstract: There is an urgent need for antivirals to treat the newly emerged SARS-CoV-2. To identify new candidates we screened a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antivirals, while screening in… read more here.
Keywords: entry pathways; drug; entry; sars cov ... See more keywords
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.05.005
Abstract: The target profiles of many drugs are established early in their development and are not systematically revisited at the time of FDA approval. Thus, it is often unclear whether therapeutics with the same nominal targets… read more here.
Keywords: establishes polypharmacology; fda approved; polypharmacology fda; profiling establishes ... See more keywords
Identification of FDA approved drugs and nucleoside analogues as potential SARS-CoV-2 A1pp domain inhibitor: An in silico study
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2020.104185
Abstract: Coronaviruses are known to infect respiratory tract and intestine. These viruses possess highly conserved viral macro domain A1pp having adenosine diphosphate (ADP)-ribose binding and phosphatase activity sites. A1pp inhibits adenosine diphosphate (ADP)-ribosylation in the host… read more here.
Keywords: cov a1pp; approved drugs; a1pp domain; drugs nucleoside ... See more keywords