The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [18F]FDDNP PET
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DOI: 10.1007/s11307-018-1210-2
Abstract: PurposeCaution is warranted when in vitro results of biomarkers labeled with tritium were perfunctorily used to criticize in vivo data and conclusions derived with the same tracers labeled with positron emitters and positron emission tomography… read more here.
Keywords: pet; value vitro; vivo; 18f fddnp ... See more keywords
Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding
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DOI: 10.1371/journal.pone.0208358
Abstract: Background The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with the apolipoprotein E (APOE) gene, has been implicated in Alzheimer’s disease (AD). TOMM40 influences AD pathology through mitochondrial neurotoxicity, and… read more here.
Keywords: tomm40 poly; fddnp; tomm40; binding ... See more keywords