Single‐Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104112
Abstract: Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear is a defining characteristic of PTSD, and the amygdala is considered the main brain region to process fear. The mechanism… read more here.
Keywords: traumatic brain; amygdala; tbi; expression ... See more keywords
Extinction and discrimination in a Bayesian model of context fear conditioning (BaconX)
Sign Up to like & getrecommendations! Published in 2021 at "Hippocampus"
DOI: 10.1002/hipo.23298
Abstract: The extinction of contextual fear is commonly an essential requirement for successful exposure therapy for fear disorders. However, experimental work on extinction of contextual fear is limited, and there little or no directly relevant theoretical… read more here.
Keywords: fear; fear conditioning; extinction; context fear ... See more keywords
Caffeine facilitates extinction of auditory fear conditioning in rats
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12287
Abstract: Caffeine is the most widely consumed psychostimulant drug which could affect learning and memory acting through central adenosine receptors. Although caffeine has been suggested to impair the acquisition and the expression of auditory fear conditioning,… read more here.
Keywords: auditory fear; caffeine; conditioning rats; caffeine facilitates ... See more keywords
Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5162-7
Abstract: RationaleDopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or basolateral amygdala.ObjectivesWe determined… read more here.
Keywords: fear; fear conditioning; sch23390; dorsomedial prefrontal ... See more keywords
Phencyclidine and Scopolamine for Modeling Amnesia in Rodents: Direct Comparison with the Use of Barnes Maze Test and Contextual Fear Conditioning Test in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9901-7
Abstract: AbstractNowadays cognitive impairments are a growing unresolved medical issue which may accompany many diseases and therapies, furthermore, numerous researchers investigate various neurobiological aspects of human memory to find possible ways to improve it. Until any… read more here.
Keywords: barnes maze; fear conditioning; maze test; test ... See more keywords
Facilitation of fear learning by prior and subsequent fear conditioning
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.03.008
Abstract: ABSTRACT Classical fear conditioning is perhaps the premier model system used to study the neurobiological basis of memory formation. Prior work has resulted in a good understanding of both the molecular mechanisms and neural circuits… read more here.
Keywords: fear; fear conditioning; fear learning; prior subsequent ... See more keywords
Fear conditioning and extinction in anxious and non-anxious youth: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Behaviour research and therapy"
DOI: 10.1016/j.brat.2019.103431
Abstract: Fear conditioning and extinction have been implicated in the etiology and maintenance of anxiety disorders. Most fear conditioning studies have been conducted with adult samples and the few published developmental studies in clinically anxious youth… read more here.
Keywords: non anxious; fear; anxious youth; extinction ... See more keywords
No robust differences in fear conditioning between patients with fear-related disorders and healthy controls.
Sign Up to like & getrecommendations! Published in 2020 at "Behaviour research and therapy"
DOI: 10.1016/j.brat.2020.103610
Abstract: Fear conditioning and extinction serve as a dominant model for the development and maintenance of pathological anxiety, particularly for phasic fear to specific stimuli or situations. The validity of this model would be supported by… read more here.
Keywords: healthy controls; fear related; fear conditioning; patients fear ... See more keywords
Predicting clinical outcomes via human fear conditioning: A narrative review.
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DOI: 10.1016/j.brat.2021.103870
Abstract: A common assumption in human fear conditioning research is that findings are informative for the etiology and treatment of clinical anxiety. One way to empirically evaluate the external validity of fear conditioning is by prospective… read more here.
Keywords: research; fear; anxiety; fear conditioning ... See more keywords
An attentional perspective on differential fear conditioning in chronic pain: The informational value of safety cues.
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DOI: 10.1016/j.brat.2021.103917
Abstract: Differences in fear conditioning between individuals suffering from chronic pain and healthy controls may indicate a learning bias that contributes to the acquisition and persistence of chronic pain. However, evidence from lab-controlled conditioning studies is… read more here.
Keywords: fear conditioning; differential fear; safety cues; chronic pain ... See more keywords
Impaired discriminative fear conditioning during later training trials differentiates generalized anxiety disorder, but not panic disorder, from healthy control participants.
Sign Up to like & getrecommendations! Published in 2018 at "Comprehensive psychiatry"
DOI: 10.1016/j.comppsych.2018.07.001
Abstract: BACKGROUND Fear conditioning is implicated as a central psychopathological mechanism of anxiety disorders. People with anxiety disorders typically demonstrate reduced affective discrimination between conditioned danger and safety cues. Here, affective discrimination refers to the ability… read more here.
Keywords: anxiety; disorder; discrimination; fear conditioning ... See more keywords