Brain activation during fear extinction predicts exposure success
Sign Up to like & getrecommendations! Published in 2017 at "Depression and Anxiety"
DOI: 10.1002/da.22583
Abstract: Exposure therapy, a gold‐standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC)… read more here.
Keywords: activation fear; extinction; extinction learning; brain activation ... See more keywords
Reproductive experience alters the involvement of N-methyl-D-aspartate receptors in fear extinction, but not fear conditioning, in female Sprague Dawley rats
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4956-y
Abstract: Recently, evidence has emerged showing that the behavioural and hormonal features of fear extinction are altered as a result of reproductive experience in both rats and humans. The current set of experiments sought to determine… read more here.
Keywords: fear extinction; extinction; methyl aspartate; reproductive experience ... See more keywords
Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5031-4
Abstract: RationalePost-traumatic stress disorder (PTSD) is a devastating anxiety-related disorder which develops subsequent to a severe psychologically traumatic event. Only ~ 9% of people who experience such a trauma develop PTSD. It is clear that a number… read more here.
Keywords: metabotropic glutamate; extinction; mglu7 receptor; receptor mrna ... See more keywords
Neural circuits for a top-down control of fear and extinction
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5033-2
Abstract: Fear learning and extinction are controlled by the activity of three interconnected regions: the amygdala, hippocampus, and prefrontal cortex. Of these, the medial prefrontal cortex modulates specific aspects in fear and extinction via a top-down… read more here.
Keywords: circuits top; extinction; top control; neural circuits ... See more keywords
Intra-prefrontal cyclosporine potentiates ketamine-induced fear extinction in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental brain research"
DOI: 10.1007/s00221-021-06050-7
Abstract: Several brain regions, including the medial prefrontal cortex (mPFC), are important in the process of fear extinction learning. Ketamine is a glutamate N-methyl-D-aspartate (NMDA) receptor antagonist, which is shown to play a role in extinction… read more here.
Keywords: cyclosporine potentiates; ketamine; extinction; intra prefrontal ... See more keywords
Differential Alterations in Cortico-Amygdala Circuitry in Mice with Impaired Fear Extinction
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01741-3
Abstract: 129S1/SvImJ (S1) mice exhibit selective impairments in fear extinction, though the mechanisms underlying these impairments are not fully understood. The medial prefrontal cortex (mPFC) consists of the prelimbic cortex (PL) and infralimbic cortex (IL), which… read more here.
Keywords: bla circuit; fear extinction; extinction; mice ... See more keywords
Administration of riluzole to the basolateral amygdala facilitates fear extinction in rats
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.08.031
Abstract: A general understanding exists that inhibition of glutamatergic neurotransmission in the basolateral amygdala (BLA) impairs fear extinction in rodents. Surprisingly, we recently found that systemic administration of riluzole, which has been shown to inhibit the… read more here.
Keywords: administration; extinction; administration riluzole; basolateral amygdala ... See more keywords
Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112798
Abstract: There is growing evidence that the neuropeptide oxytocin (OT) modulates fear and extinction in humans and rodents through actions in corticolimbic circuits including the central amygdala (CeA). Prior studies have, however, been limited to subjects… read more here.
Keywords: selective sub; effects intra; extinction; sub nucleus ... See more keywords
Fear Extinction Retention: Is It What We Think It Is?
Sign Up to like & getrecommendations! Published in 2019 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2019.02.011
Abstract: There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain… read more here.
Keywords: retention think; extinction retention; extinction; fear extinction ... See more keywords
Maximizing the generalization of fear extinction: Exposures to a peak generalization stimulus.
Sign Up to like & getrecommendations! Published in 2018 at "Behaviour research and therapy"
DOI: 10.1016/j.brat.2018.09.005
Abstract: Experimental research has shown that generalization of fear extinction from a generalization stimulus (GS) is minimal compared to generalization of fear extinction from the conditional stimulus itself (CS+). This poses a challenge to extinction-based treatments… read more here.
Keywords: generalization; stimulus; generalization fear; extinction ... See more keywords
The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.089
Abstract: Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for… read more here.
Keywords: motor kif21b; fear extinction; extinction; activation ... See more keywords