The effect of transcutaneous vagus nerve stimulation on fear generalization and subsequent fear extinction
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.04.006
Abstract: Fear overgeneralization is thought to be one of the cardinal processes underlying anxiety disorders, and a determinant of the onset, maintenance and recurrence of these disorders. Animal studies have shown that stimulating the vagus nerve… read more here.
Keywords: fear generalization; fear; extinction; vagus nerve ... See more keywords
Corticosterone differentially modulates time-dependent fear generalization following mild or moderate fear conditioning training in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of learning and memory"
DOI: 10.1016/j.nlm.2021.107487
Abstract: Stressful and emotionally arousing experiences create strong memories that seem to lose specificity over time. It is uncertain, however, how the stress system contributes to the phenomenon of time-dependent fear generalization. Here, we investigated whether… read more here.
Keywords: fear generalization; fear; time; training ... See more keywords
Increased fear generalization and amygdala AMPA receptor proteins in chronic traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0119
Abstract: Cognitive impairments and emotional lability are common long-term consequences of traumatic brain injury (TBI). How TBI affects interactions between sensory, cognitive, and emotional systems may reveal mechanisms that underlie chronic mental health comorbidities. Previously, we… read more here.
Keywords: shock; tbi; injury; fear generalization ... See more keywords
52. Abnormal Anterior Insula Activity During Fear Generalization in Schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbx021.071
Abstract: Abstract Background: Generalization from previous experiences allows us to evaluate the affective value of novel events. A breakdown of this fundamental ability may lead to incorrect attributions of affective value that could give rise to psychotic… read more here.
Keywords: fear generalization; phase; generalization; schizophrenia ... See more keywords
GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.16123
Abstract: Fear overgeneralization is widely accepted as a pathogenic marker of post‐traumatic stress disorder (PTSD). Recently, GABAergic interneurons have been regarded as key players in the regulation of fear memory. The role of hippocampal GABAergic interneurons… read more here.
Keywords: fear generalization; ptsd rats; gabaergic interneurons; ptsd ... See more keywords
Generalized fear after acute stress is caused by change in neuronal cotransmitter identity
Sign Up to like & getrecommendations! Published in 2024 at "Science"
DOI: 10.1126/science.adj5996
Abstract: Overgeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. In this study, we show that generalized… read more here.
Keywords: generalized fear; stress; fear generalization; change ... See more keywords
No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811241261375
Abstract: Background: The neurotransmitter dopamine plays an important role in the processing of emotional memories, and prior research suggests that dopaminergic manipulations immediately after fear learning can affect the retention and generalization of acquired fear. Aims:… read more here.
Keywords: post training; dopamine; fear generalization; generalization ... See more keywords
Ventral Pallidum Neurons Are Necessary to Generalize and Express Fear-Related Responding in a Minimal Threat Setting
Sign Up to like & getrecommendations! Published in 2024 at "eNeuro"
DOI: 10.1523/eneuro.0124-24.2024
Abstract: Fear generalization is a hallmark of anxiety disorders. Experimentally, fear generalization can be difficult to dissociate from its counterpart, fear discrimination. Here, we use minimal threat learning procedures to reveal such a dissociation. We show… read more here.
Keywords: fear generalization; threat; fear; ventral pallidum ... See more keywords
Sex Differences in Remote Contextual Fear Generalization in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2019.00056
Abstract: The generalization of fear is adaptive in that it allows an animal to respond appropriately to novel threats that are not identical to previous experiences. In contrast, the overgeneralization of fear is maladaptive and is… read more here.
Keywords: fear generalization; generalization; fear; sex differences ... See more keywords
Fear Generalization Towards a Stimulus and Context and the Impact of Attention Bias
Sign Up to like & getrecommendations! Published in 2024 at "Behavioral Sciences"
DOI: 10.3390/bs14121230
Abstract: Fear overgeneralization is a prevalent clinical symptom of anxiety disorders. Various research studies have demonstrated that attention plays a crucial role in fear generalization. Moreover, fear is not only generalized to the stimulus, but individuals… read more here.
Keywords: attention; fear generalization; generalization; attention bias ... See more keywords