Cholinergic regulation of fear learning and extinction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23840
Abstract: Cholinergic activation regulates cognitive function, particularly long‐term memory consolidation. This Review presents an overview of the anatomical, neurochemical, and pharmacological evidence supporting the cholinergic regulation of Pavlovian contextual and cue‐conditioned fear learning and extinction. Basal… read more here.
Keywords: fear learning; extinction; learning extinction; role ... See more keywords
Dorsal hippocampal interleukin-1 signaling mediates heroin withdrawal-enhanced fear learning.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05645-2
Abstract: Converging evidence suggests opioid abuse can increase the incidence and severity of post-traumatic stress disorder (PTSD) in clinical populations. Interestingly, opioid withdrawal alone can produce symptoms similar to those of PTSD. Despite this association, the… read more here.
Keywords: withdrawal; fear learning; heroin withdrawal; enhanced fear ... See more keywords
Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.09.016
Abstract: Post-traumatic stress disorder (PTSD) is associated with immune dysregulation. We have previously shown that severe stress exposure in a preclinical animal model of the disorder, stress-enhanced fear learning (SEFL), is associated with an increase in… read more here.
Keywords: fear learning; sefl; enhanced fear; stress ... See more keywords
Facilitation of fear learning by prior and subsequent fear conditioning
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.03.008
Abstract: ABSTRACT Classical fear conditioning is perhaps the premier model system used to study the neurobiological basis of memory formation. Prior work has resulted in a good understanding of both the molecular mechanisms and neural circuits… read more here.
Keywords: fear; fear conditioning; fear learning; prior subsequent ... See more keywords
One-trial overshadowing: Evidence for fast specific fear learning in humans.
Sign Up to like & getrecommendations! Published in 2017 at "Behaviour research and therapy"
DOI: 10.1016/j.brat.2016.12.001
Abstract: Adaptive defensive actions necessitate a fear learning system that is both fast and specific. Fast learning serves to minimize the number of threat confrontations, while specific learning ensures that the acquired fears are tied to… read more here.
Keywords: trial; fast specific; fear; fear learning ... See more keywords
Fear learning, avoidance, and generalization are more context-dependent for adults than adolescents.
Sign Up to like & getrecommendations! Published in 2021 at "Behaviour research and therapy"
DOI: 10.1016/j.brat.2021.103993
Abstract: This study examined developmental differences in contextual and perceptual generalization of fear and avoidance learning. Adults (N = 39) and adolescents (N = 44) completed differential fear acquisition wherein each conditional stimulus (CS) appeared in a background context. In… read more here.
Keywords: generalization; context; fear learning; avoidance generalization ... See more keywords
Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.083
Abstract: SUMMARY Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF neurons release GABA and several neuropeptides predicted to play important yet opposing roles in these behaviors. We dissected… read more here.
Keywords: fear learning; anxiety fear; roles gaba; crf dynorphin ... See more keywords
Estrogen, progesterone, and the menstrual cycle: A systematic review of fear learning, intrusive memories, and PTSD.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical psychology review"
DOI: 10.1016/j.cpr.2018.06.005
Abstract: Women are disproportionately affected by posttraumatic stress disorder (PTSD), and gonadal hormones are implicated in fear learning processes associated with PTSD. In rodents, lower estradiol, particularly during metestrus when progesterone is also low, is associated… read more here.
Keywords: symptomatology; fear; fear learning; systematic review ... See more keywords
A Situation-Aware Fear Learning (SAFEL) model for robots
Sign Up to like & getrecommendations! Published in 2017 at "Neurocomputing"
DOI: 10.1016/j.neucom.2016.09.035
Abstract: This work proposes a novel Situation-Aware FEar Learning (SAFEL) model for robots. SAFEL combines concepts of situation-aware expert systems with well-known neuroscientific findings on the brain fear-learning mechanism to allow companion robots to predict undesirable… read more here.
Keywords: situation aware; learning safel; fear; aware fear ... See more keywords
Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.12.030
Abstract: Fear learning is a fundamental behavioral process that requires dopamine (DA) release. Experience-dependent synaptic plasticity occurs on DA neurons while an organism is engaged in aversive experiences. However, whether synaptic plasticity onto DA neurons is… read more here.
Keywords: plasticity onto; onto dopamine; fear learning; synaptic plasticity ... See more keywords
Social Fear Learning: from Animal Models to Human Function
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Cognitive Sciences"
DOI: 10.1016/j.tics.2017.04.010
Abstract: Learning about potential threats is critical for survival. Learned fear responses are acquired either through direct experiences or indirectly through social transmission. Social fear learning (SFL), also known as vicarious fear learning, is a paradigm… read more here.
Keywords: fear; fear learning; social fear; learning animal ... See more keywords