The effect of stress and reward on encoding future fear memories
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113587
Abstract: Prior experience changes the way we learn about our environment. Stress predisposes individuals to developing psychological disorders, just as positive experiences protect from this eventuality (Kirkpatrick & Heller, 2014; Koenigs & Grafman, 2009; Pechtel &… read more here.
Keywords: fear; fear memories; stress reward; effect stress ... See more keywords
Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.09.013
Abstract: Disinhibitory neurons throughout the mammalian cortex are powerful enhancers of circuit excitability and plasticity. The differential expression of neuropeptide receptors in disinhibitory, inhibitory, and excitatory neurons suggests that each circuit motif may be controlled by… read more here.
Keywords: grp; peptide; recruits disinhibitory; fear memories ... See more keywords
Alpha1-adrenergic receptor blockade in the VTA modulates fear memories and stress responses
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.05.008
Abstract: Activity of the ventral tegmental area (VTA) and its terminals has been implicated in the Pavlovian associative learning of both stressful and rewarding stimuli. However, the role of the VTA noradrenergic signaling in fear responses… read more here.
Keywords: vta; alpha1 adrenergic; fear memories; adrenergic receptor ... See more keywords
Cathodal transcranial direct current stimulation on the prefrontal cortex applied after reactivation attenuates fear memories and prevent reinstatement after extinction.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.12.025
Abstract: BACKGROUND In the last decade, pharmacological strategies targeting reconsolidation after memory retrieval have shown promising efforts to attenuate persistent memories and overcome fear recovery. However, most reconsolidation inhibiting agents have not been approved for human… read more here.
Keywords: fear memories; reactivation; cathodal; extinction ... See more keywords
Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.05.22.492937
Abstract: Histone acetylation is a key component in the consolidation of long-term fear memories. Epigenetic enzymes involved in histone acetylation, including histone acetyltransferases and deacetylases, have been put forward as potential pharmacological targets in the treatment… read more here.
Keywords: acetyl coa; histone acetylation; fear memories;
Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001789
Abstract: Long-term memory formation involves the reorganization of brain circuits, termed system consolidation. Whether and how a prior fear experience influences system consolidation of new memories is poorly understood. In rats, we found that prior auditory… read more here.
Keywords: prior fear; fear learning; system consolidation; fear ... See more keywords
Median raphe region stimulation alone generates remote, but not recent fear memory traces
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0181264
Abstract: The median raphe region (MRR) is believed to control the fear circuitry indirectly, by influencing the encoding and retrieval of fear memories by amygdala, hippocampus and prefrontal cortex. Here we show that in addition to… read more here.
Keywords: median raphe; mrr; fear; stimulation ... See more keywords
Berberine Facilitates Extinction and Prevents the Return of Fear
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.748995
Abstract: Exposure to a catastrophic event or intense stimulation can trigger fear memories, and the threatening memories persist even over a lifetime. Exposure therapy is based on extinction learning and is widely used to treat fear-related… read more here.
Keywords: extinction; facilitates extinction; berberine; fear memories ... See more keywords