Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202500177
Abstract: Despite the known benefits of exercise, an in‐depth comparison of the effects of regular versus irregular exercise on brain–body interactions and molecular mechanisms remains lacking. This study demonstrates that regular exercise robustly enhances fear memory… read more here.
Keywords: memory extinction; versus irregular; fear memory; irregular exercise ... See more keywords
Subicular Astrocytes Govern Seizure-Impaired Fear Memory.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202510818
Abstract: The mechanisms underlying seizure-associated cognitive impairment remain incompletely characterized. Emerging evidence positions the subiculum, a hippocampal output hub critically involved in both epileptic seizure and cognitive performance, as a putative nexus for this comorbidity. Here,… read more here.
Keywords: memory; subicular astrocytes; fear memory; seizure ... See more keywords
Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation-induced fear memory impairment in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3013
Abstract: INTRODUCTION Regulation of brain-derived neurotrophic factor (BDNF) in the basal forebrain ameliorates sleep deprivation-induced fear memory impairments in rodents. Antisense oligonucleotides (ASOs) targeting ATXN2 was a potential therapy for spinocerebellar ataxia, whose pathogenic mechanism associates… read more here.
Keywords: deprivation induced; sleep deprivation; fear memory; memory ... See more keywords
Elimination of perineuronal nets in CA1 disrupts GABA release and long-term contextual fear memory retention.
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23503
Abstract: Perineuronal nets (PNNs) which mostly surround the parvalbumin (PV) neurons, have been shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate fear-associated memory, but the molecular mechanism is still… read more here.
Keywords: long term; term contextual; perineuronal nets; fear memory ... See more keywords
Amygdala‐Dependent Signaling Pathways and Regulating Circuits in Fear Memory
Sign Up to like & getrecommendations! Published in 2025 at "Synapse"
DOI: 10.1002/syn.70026
Abstract: Fear memory, a profound emotional memory formed in response to threatening events, is vital to the survival and adaptation of individuals. The amygdala, a central hub in the formation, storage, and expression of fear memory,… read more here.
Keywords: circuits fear; signaling pathways; memory; amygdala dependent ... See more keywords
The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05573-1
Abstract: The mechanistic target of rapamycin (mTOR) kinase mediates various long-lasting forms of synaptic and behavioural plasticity. However, there is little information concerning the temporal pattern of mTOR activation and susceptibility to pharmacological intervention during consolidation… read more here.
Keywords: consolidation; inhibitor; fear memory; persistence ... See more keywords
NRG1 accelerates the forgetting of fear memories and facilitates the induction of long-term depression in adult mice.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05877-w
Abstract: RATIONALE Forgetting of fear memory is a current medical therapy for posttraumatic stress disorder (PTSD), and hippocampal long-term depression (LTD) may be the underlying mechanism. Neuregulin 1 (NRG1), a trophic factor, reportedly modulates memory consolidation… read more here.
Keywords: adult; long term; fear memory; forgetting fear ... See more keywords
Microglial production of TNF-alpha is a key element of sustained fear memory
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.08.011
Abstract: The proinflammatory cytokine productions in the brain are altered in a process of fear memory formation, indicating a possibility that altered microglial function may contribute to fear memory formation. We aimed to investigate whether and… read more here.
Keywords: mice representing; tnf; microglia mice; fear memory ... See more keywords
Dopamine and norepinephrine transporter inhibition for long-term fear memory enhancement
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112266
Abstract: Psychostimulants are highly effective cognitive-enhancing therapeutics yet have a significant potential for abuse and addiction. While psychostimulants likely exert their rewarding and addictive properties through dopamine transporter (DAT) inhibition, the mechanisms of their procognitive effects… read more here.
Keywords: long term; inhibition; fear memory; dat ... See more keywords
Amyloid-beta (1-42) lesion of CA1 rat dorsal hippocampus reduces contextual fear memory and increases expression of microglial genes regulating neuroinflammation
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112795
Abstract: Emerging evidence indicates that the pathogenesis of Alzheimer's disease (AD) is not confined to neuronal disruptions but robustly communicates with the brain's immune system. Genome-wide analysis suggests that several genes, which increase the risk for… read more here.
Keywords: memory; genes regulating; neuroinflammation; fear memory ... See more keywords
Inhibition of Piezo1/Ca2+/calpain signaling in the rat basal forebrain reverses sleep deprivation-induced fear memory impairments
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113594
Abstract: In this study, we tested the hypothesis that the Piezo1/Ca2+/calpain pathway of the basal forebrain (BF) modulates impaired fear conditioning caused by sleep deprivation. Adult male Wistar rats were subjected to 6h of total sleep… read more here.
Keywords: deprivation induced; sleep deprivation; piezo1; fear memory ... See more keywords