Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation-induced fear memory impairment in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3013
Abstract: INTRODUCTION Regulation of brain-derived neurotrophic factor (BDNF) in the basal forebrain ameliorates sleep deprivation-induced fear memory impairments in rodents. Antisense oligonucleotides (ASOs) targeting ATXN2 was a potential therapy for spinocerebellar ataxia, whose pathogenic mechanism associates… read more here.
Keywords: deprivation induced; sleep deprivation; fear memory; memory ... See more keywords
Elimination of perineuronal nets in CA1 disrupts GABA release and long-term contextual fear memory retention.
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23503
Abstract: Perineuronal nets (PNNs) which mostly surround the parvalbumin (PV) neurons, have been shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate fear-associated memory, but the molecular mechanism is still… read more here.
Keywords: long term; term contextual; perineuronal nets; fear memory ... See more keywords
The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05573-1
Abstract: The mechanistic target of rapamycin (mTOR) kinase mediates various long-lasting forms of synaptic and behavioural plasticity. However, there is little information concerning the temporal pattern of mTOR activation and susceptibility to pharmacological intervention during consolidation… read more here.
Keywords: consolidation; inhibitor; fear memory; persistence ... See more keywords
NRG1 accelerates the forgetting of fear memories and facilitates the induction of long-term depression in adult mice.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05877-w
Abstract: RATIONALE Forgetting of fear memory is a current medical therapy for posttraumatic stress disorder (PTSD), and hippocampal long-term depression (LTD) may be the underlying mechanism. Neuregulin 1 (NRG1), a trophic factor, reportedly modulates memory consolidation… read more here.
Keywords: adult; long term; fear memory; forgetting fear ... See more keywords
Microglial production of TNF-alpha is a key element of sustained fear memory
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.08.011
Abstract: The proinflammatory cytokine productions in the brain are altered in a process of fear memory formation, indicating a possibility that altered microglial function may contribute to fear memory formation. We aimed to investigate whether and… read more here.
Keywords: mice representing; tnf; microglia mice; fear memory ... See more keywords
Dopamine and norepinephrine transporter inhibition for long-term fear memory enhancement
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112266
Abstract: Psychostimulants are highly effective cognitive-enhancing therapeutics yet have a significant potential for abuse and addiction. While psychostimulants likely exert their rewarding and addictive properties through dopamine transporter (DAT) inhibition, the mechanisms of their procognitive effects… read more here.
Keywords: long term; inhibition; fear memory; dat ... See more keywords
Amyloid-beta (1-42) lesion of CA1 rat dorsal hippocampus reduces contextual fear memory and increases expression of microglial genes regulating neuroinflammation
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112795
Abstract: Emerging evidence indicates that the pathogenesis of Alzheimer's disease (AD) is not confined to neuronal disruptions but robustly communicates with the brain's immune system. Genome-wide analysis suggests that several genes, which increase the risk for… read more here.
Keywords: memory; genes regulating; neuroinflammation; fear memory ... See more keywords
Inhibition of Piezo1/Ca2+/calpain signaling in the rat basal forebrain reverses sleep deprivation-induced fear memory impairments
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113594
Abstract: In this study, we tested the hypothesis that the Piezo1/Ca2+/calpain pathway of the basal forebrain (BF) modulates impaired fear conditioning caused by sleep deprivation. Adult male Wistar rats were subjected to 6h of total sleep… read more here.
Keywords: deprivation induced; sleep deprivation; piezo1; fear memory ... See more keywords
Oxytocin receptor antagonist atosiban impairs consolidation, but not reconsolidation of contextual fear memory in rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.05.034
Abstract: There is increasing evidence that oxytocin is involved in learning and memory process. This study investigated the effects of blockade of oxytocin receptors using the selective oxytocin receptor antagonist atosiban (ATO) on contextual fear memory… read more here.
Keywords: contextual fear; memory; consolidation reconsolidation; fear memory ... See more keywords
Diazepam suppresses the stress‐induced dopaminergic release in the amygdala of methamphetamine‐sensitized rat
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.048
Abstract: Abstract Although the benzodiazepine class of drugs has proven useful in treating anxiety symptoms, recent studies yield no consistent empirical support for their use in treating psychiatric disorders. However, animal studies using a fear conditioning… read more here.
Keywords: memory processing; amygdala methamphetamine; fear memory; effect ... See more keywords
Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173768
Abstract: Phosphodiesterase 2 is one of the phosphodiesterase (PDEs) family members that regulate cyclic nucleotide (namely cAMP and cGMP) concentrations. The present study determined whether PDE2 inhibition could rescue post-traumatic stress disorder (PTSD)-like symptoms. Mice were… read more here.
Keywords: bay 7550; inhibitor; fear memory; phosphodiesterase ... See more keywords