Single‐Cell RNA‐Seq and Machine Learning Reveal Key Feature Genes of Astrocyte in Perioperative Neurocognitive Disorders
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.70085
Abstract: Perioperative neurocognitive disorder (PND) is common in older patients after anesthesia and surgery, significantly increasing morbidity and mortality. However, the role of astrocytes in its pathogenesis remains limitedly understood. Here, we analyzed 9976 and 9484… read more here.
Keywords: single cell; feature genes; machine learning; perioperative neurocognitive ... See more keywords
Multi‐dataset identification of innovative feature genes and molecular mechanisms in keratoconus
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70079
Abstract: This study aimed to identify feature genes and explore the molecular mechanisms of keratoconus (KC). We downloaded data files from NCBI GEO public database. The Limma package was used for differential expression analysis of gene… read more here.
Keywords: expression levels; mechanisms keratoconus; feature genes; molecular mechanisms ... See more keywords
In Silico Identification of Key Genes and Immune Infiltration Characteristics in Epicardial Adipose Tissue from Patients with Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5610317
Abstract: Background The present study is aimed at identifying the differentially expressed genes (DEGs) and relevant biological processes and pathways associated with epicardial adipose tissue (EAT) from patients with coronary artery disease (CAD). We also explored… read more here.
Keywords: infiltration; feature; epicardial adipose; feature genes ... See more keywords
Developing the new diagnostic model by integrating bioinformatics and machine learning for osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-024-05340-4
Abstract: Osteoarthritis (OA) is a common cause of disability among the elderly, profoundly affecting quality of life. This study aims to leverage bioinformatics and machine learning to develop an artificial neural network (ANN) model for diagnosing… read more here.
Keywords: feature genes; machine learning; model; diagnostic model ... See more keywords
The underlying molecular mechanisms and biomarkers of Hip fracture combined with deep vein thrombosis based on self sequencing bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-025-05668-5
Abstract: Thrombus formation is a severe complication in orthopedic surgery, significantly increasing mortality in patients with fractures. Therefore, identifying feature genes to determine thrombus presence in fracture surgeries is critical. Whole blood samples were collected from… read more here.
Keywords: fracture; analysis; feature genes; thrombosis ... See more keywords
Identification of the feature genes involved in cytokine release syndrome in COVID-19
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DOI: 10.1371/journal.pone.0296030
Abstract: Objective Screening of feature genes involved in cytokine release syndrome (CRS) from the coronavirus disease 19 (COVID-19). Methods The data sets related to COVID-19 were retrieved using Gene Expression Omnibus (GEO) database, the differentially expressed… read more here.
Keywords: covid; involved cytokine; feature genes; genes involved ... See more keywords
FOXO4 May Be a Biomarker of Postmenopausal Osteoporosis
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DOI: 10.2147/ijgm.s347416
Abstract: Purpose Postmenopausal osteoporosis (PMOP) is a common and debilitating chronic disease, but it has just no cure options. The objective of this study was to identify genes associated with osteoporosis and reveal potential therapeutic targets.… read more here.
Keywords: feature genes; differentially expressed; postmenopausal osteoporosis; foxo4 may ... See more keywords
Identification of mitochondria-related feature genes for predicting type 2 diabetes mellitus using machine learning methods
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2025.1501159
Abstract: Purpose We aimed to identify the mitochondria-related feature genes associated with type 2 diabetes mellitus and explore their potential roles in immune cell infiltration. Methods Datasets from GSE41762, GSE38642, GSE25724, and GSE20966 were obtained from… read more here.
Keywords: diabetes mellitus; type diabetes; feature genes; mitochondria related ... See more keywords
Unveiling Immune-related feature genes for Alzheimer’s disease based on machine learning
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DOI: 10.3389/fimmu.2024.1333666
Abstract: The identification of diagnostic and therapeutic biomarkers for Alzheimer’s Disease (AD) remains a crucial area of research. In this study, utilizing the Weighted Gene Co-expression Network Analysis (WGCNA) algorithm, we identified RHBDF2 and TNFRSF10B as… read more here.
Keywords: alzheimer disease; feature genes; rhbdf2 tnfrsf10b;
Novel Immune-Related Genetic Expression for Primary Sjögren's Syndrome
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DOI: 10.3389/fmed.2021.719958
Abstract: Objective: To identify novel immune-related genes expressed in primary Sjögren's syndrome (pSS). Methods: Gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were screened. The differences in… read more here.
Keywords: expression; feature genes; gren syndrome; immune related ... See more keywords
Immunogenic cell death-led discovery of COVID-19 biomarkers and inflammatory infiltrates
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1191004
Abstract: Immunogenic cell death (ICD) serves a critical role in regulating cell death adequate to activate an adaptive immune response, and it is associated with various inflammation-related diseases. However, the specific role of ICD-related genes in… read more here.
Keywords: cell death; covid; immunogenic cell; feature genes ... See more keywords