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Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1697
Abstract: Hyperuricemia has been associated with chronic kidney disease (CKD) progression. The antihyperuricemic febuxostat's potential renoprotective effect has been demonstrated in stage 1–3 CKD. Large‐scale studies comparing the renoprotective potential of febuxostat and allopurinol in advanced…
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Keywords:
predialysis stage;
febuxostat;
stage;
febuxostat allopurinol ... See more keywords
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Published in 2020 at "Joint bone spine"
DOI: 10.1016/j.jbspin.2020.03.017
Abstract: OBJECTIVE Urate-lowering treatment (ULT) is recommended in gout management. However, initiation of ULT during an acute gout flare is still inconclusive. This study aimed to evaluate the efficacy and safety of the ULT febuxostat administered…
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Keywords:
gout attack;
febuxostat;
acute gout;
initiation ... See more keywords
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Published in 2020 at "The Lancet"
DOI: 10.1016/s0140-6736(20)32234-0
Abstract: BACKGROUND Febuxostat and allopurinol are urate-lowering therapies used to treat patients with gout. Following concerns about the cardiovascular safety of febuxostat, the European Medicines Agency recommended a post-licensing study assessing the cardiovascular safety of febuxostat…
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Keywords:
allopurinol;
patients gout;
non;
febuxostat ... See more keywords
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Published in 2018 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2018.1498842
Abstract: ABSTRACT Introduction: Febuxostat is a potent non-purine selective xanthine oxidase inhibitor approved by the FDA in 2009 for management of hyperuricemia in people with gout. Areas covered: The authors summarize the pre-clinical studies and pivotal…
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Keywords:
gout;
febuxostat;
treatment hyperuricaemia;
hyperuricaemia gout ... See more keywords
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Published in 2019 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfz106.fp278
Abstract: Type : Oral Abstract Submission No. : OR-1280 The Inhibition of Xanthine Oxidoreductase by Febuxostat Ameliorates Oxidative Stress in Contrast Induced Nephropathy through the AMPK-NOXsHIF-1α Signaling in Mice Yu Ah Hong, Keum Jin Yang, Jung…
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Keywords:
nephrology;
ampk;
febuxostat;
inhibition ... See more keywords
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Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001326
Abstract: ABSTRACT Atherosclerosis (AS) is a common cardiovascular disease with high morbidity and mortality. The pathogenesis of AS is closely related to endothelial dysfunction, which is mainly induced by oxidative stress, inflammation, and enhanced adhesion of…
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Keywords:
induced injury;
injury monocyte;
febuxostat;
ldl ... See more keywords
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Published in 2017 at "American journal of therapeutics"
DOI: 10.1097/mjt.0000000000000565
Abstract: Successful gout treatment depends almost entirely on lowering serum urate levels.1 Over the last decade, the Food and Drug Administration (FDA) approved 3 new urate-lowering medications: febuxostat, pegloticase, and lesinurad (joining the long-ago-approved drugs allopurinol…
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Keywords:
uric acid;
febuxostat;
trial;
drug ... See more keywords
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Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-218056
Abstract: We read with great interest the study by Singh and Cleveland1 that investigated the risk of hypersensitivity reactions (HRs) with allopurinol and febuxostat using Medicare claims data. These authors analysed a national cohort in the…
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Keywords:
febuxostat;
medicare claims;
using medicare;
claims data ... See more keywords
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Published in 2019 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-019-1556-z
Abstract: Febuxostat (FXT) is a xanthine oxidase (XO) drug which indicated for the treatment of gout. FXT loaded nanosized ethosomes were prepared using cold method with varied concentrations of ethyl alcohol and soya lecithin (SL). The…
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Keywords:
febuxostat;
vivo;
study;
drug ... See more keywords
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Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1927-p
Abstract: Hyperuricemia is closely associated with various metabolic disorders such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases. Xanthine oxidoreductase (XOR) is a key enzyme known to catalyze purines to uric acid. Febuxostat is an orally-active, potent,…
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Keywords:
skeletal muscle;
febuxostat;
ltd;
effect ... See more keywords
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Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.905828
Abstract: Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects…
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Keywords:
dox;
cardioprotective effects;
combination;
febuxostat ... See more keywords