Single-cell RNA-seq reveals the effects of the FecB mutation on the transcriptome profile in ovine cumulus cells
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DOI: 10.1038/s41598-024-64001-y
Abstract: Genetic variations in the ovine ovulation rate, which are associated with the FecB mutation, provide useful models by which to explore the mechanisms regulating the development of mammalian antral follicles. In order to study the… read more here.
Keywords: cumulus; cell; fecb mutation; cumulus cells ... See more keywords
A meta-analysis of mRNA expression profiling studies in sheep with different FecB genotypes.
Sign Up to like & getrecommendations! Published in 2023 at "Animal genetics"
DOI: 10.1111/age.13304
Abstract: The FecB mutation in the sheep BMPRIB is strongly correlated with high ovulation traits but its mechanism remains unclear. This study explored differentially expressed genes (DEGs) and their associated molecular mechanisms that may be involved… read more here.
Keywords: sheep different; fecb genotypes; analysis; fecb mutation ... See more keywords
Development and validation of a simple, cost-effective competitive allele-specific PCR assay for largescale screening and detection of FecB mutation in sheep
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DOI: 10.1371/journal.pone.0337392
Abstract: The Booroola fecundity (FecB) gene, a mutation in the bone morphogenetic protein receptor-1B (BMPR1B), is known to increase ovulation rate and litter size in sheep. Efficient and accurate, large-scale detection of this single nucleotide polymorphism… read more here.
Keywords: sheep; pcr; mutation; fecb mutation ... See more keywords
Integrated Proteotranscriptomics of the Hypothalamus Reveals Altered Regulation Associated with the FecB Mutation in the BMPR1B Gene That Affects Prolificacy in Small Tail Han Sheep
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DOI: 10.3390/biology12010072
Abstract: Simple Summary Increasing sheep litter size is essential to improve lamb production efficiency. In Small Tail Han sheep, the large variation in litter size is determined by segregation of the bone morphogenetic receptor type 1B… read more here.
Keywords: small tail; fecb mutation; type; receptor ... See more keywords