Mimicking regional and fasted/fed state conditions in the intestine with the mucus‐PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.02.035
Abstract: ABSTRACT Intestinal drug absorption following oral administration can be influenced by regional conditions (absorbing surface area, bacterial flora, motility, pH, mucus thickness) and food intake, all of which affect drug solubility and permeability. Therefore, it… read more here.
Keywords: mucus pvpa; fed state; mucus; permeability ... See more keywords
Exploring gastric drug absorption in fasted and fed state rats
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.07.017
Abstract: ABSTRACT The small intestine is generally considered the major site of absorption after oral drug administration. Absorption from the stomach is often disregarded, though passive diffusion across the gastric mucosal barrier is theoretically possible. In… read more here.
Keywords: absorption; state; fasted fed; fed state ... See more keywords
mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.12.003
Abstract: Objective Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles… read more here.
Keywords: fed state; hyperlipidemia; mtorc1; lipolysis ... See more keywords
Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature ("Magenstraße") in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00778
Abstract: The objective of the present study was to develop an in silico model of the stomach for predicting oral drug absorption in fed humans. We focused on a model capable of simulating dynamic fluid volume… read more here.
Keywords: gastric emptying; fed state; secretion; vivo performance ... See more keywords
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.
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DOI: 10.1021/acs.molpharmaceut.8b00736
Abstract: Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI) tract remains challenging. Many in vivo techniques are available to investigate the impact of GI physiology on oral drug behavior in… read more here.
Keywords: state; fed state; state conditions; drug ... See more keywords
The Influence of Fed State Lipolysis Inhibition on the Intraluminal Behaviour and Absorption of Fenofibrate from a Lipid-Based Formulation
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DOI: 10.3390/pharmaceutics14010119
Abstract: The bioavailability of lipophilic drugs may or may not be increased when administered with food due to increased solubilisation in fed state gastrointestinal (GI) fluids. The in vivo interplay between drug solubilisation, lipid phase digestion… read more here.
Keywords: absorption; fenofibrate; fed state; lipolysis ... See more keywords