Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells.
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DOI: 10.1016/j.bbrc.2017.07.002
Abstract: The current study evaluated the potential anti-colorectal cancer (CRC) activity by Ku-0060648, a novel DNA-PKcs and PI3K duel inhibitor. In both CRC cell lines (HCT-116 and HT-29) and primary human colon cancer cells, Ku-0060648 exposure… read more here.
Keywords: autophagy activation; colorectal cancer; feedback autophagy; crc ... See more keywords