NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR‐Akt feedback loop that activates autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13230
Abstract: Low responsiveness to chemotherapy is an important cause of poor prognosis in pancreatic cancer. Smoking is a high‐risk factor for pancreatic cancer and cancer resistance to gemcitabine; however, the underlying mechanisms remain unclear. 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)… read more here.
Keywords: cell; pancreatic cancer; 2ar akt; cancer ... See more keywords
Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201414
Abstract: Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites… read more here.
Keywords: acid; transport; negative feedback; conjugation ... See more keywords
lncRNA‐NKILA/NF‐κB feedback loop modulates laryngeal cancer cell proliferation, invasion, and radioresistance
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1405
Abstract: Laryngeal cancer is one of the most common head and neck malignant tumors and is commonly resistant to X‐ray‐based radiotherapy. NF‐κB interacting lncRNA (NKILA) has been reported to serve as a tumor suppressor in several… read more here.
Keywords: lncrna nkila; laryngeal cancer; feedback loop; cancer cell ... See more keywords
COL11A1‐driven positive feedback loop modulates fibroblast transformation and activates pancreatic cancer progression
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.12009
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most common leading causes of cancer death. The cancer‐associated fibroblasts (CAFs) in the tumor microenvironment (TME) aggravate the malignant behavior of PDAC. However, it is still unknown… read more here.
Keywords: driven positive; col11a1 driven; pdac; cancer ... See more keywords
Activation of EGFR‐KLF4 positive feedback loop results in acquired resistance to sorafenib in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23102
Abstract: Sorafenib is the standard first‐line systemic chemotherapeutic drugs for advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib is frequently observed in clinical practice. In this study, we first produced three sorafenib resistance (SR) HCC… read more here.
Keywords: positive feedback; hcc; feedback loop; sorafenib ... See more keywords
Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-95294-9_4
Abstract: Cells communicate constantly with their surrounding extracellular matrix (ECM) to maintain homeostasis, using both mechanical and chemical signals. In cancer, abnormal signaling leads to stiffening of the ECM. A stiff microenvironment affects many aspects of… read more here.
Keywords: matrix stiffness; feedback loop; extracellular matrix; matrix ... See more keywords
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02678-6
Abstract: The clinical success of immune checkpoint blockade against diverse human cancers highlights the critical importance of insightful understanding into mechanisms underlying PD-L1 regulation. IFN-γ released by intratumoral lymphocytes regulates PD-L1 expression in tumor cells through… read more here.
Keywords: positive feedback; feedback loop; cancer; irf1 ... See more keywords
LncRNA FIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.194
Abstract: Stroke is one of the leading causes for serious long-term neurological disability. LncRNAs have been investigated to be dysregulated in ischemic stroke. However, the underlying mechanisms of some specific lncRNAs have not been clearly clarified.… read more here.
Keywords: feedback loop; cerebral microglial; ogd injury; microglial cells ... See more keywords
XTP8 promotes hepatocellular carcinoma growth by forming a positive feedback loop with FOXM1 oncogene.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.164
Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancer in the world and the main cause of cancer death. Chronic hepatitis B virus (HBV) infection is the major cause of HCC. HBx, as a… read more here.
Keywords: hepatocellular carcinoma; hcc; feedback loop; expression ... See more keywords
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.092
Abstract: SUMMARY Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report… read more here.
Keywords: positive feedback; liver fibrosis; feedback loop; tgf ... See more keywords
Screech feedback loop and mode staging process of axisymmetric underexpanded jets
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Thermal and Fluid Science"
DOI: 10.1016/j.expthermflusci.2020.110323
Abstract: Abstract Acoustic measurements and time-resolved schlieren visualizations are performed on underexpanded jets issuing from a convergent nozzle to investigate the screech feedback loop and the mode staging phenomenon. In the present experiments, the nozzle pressure… read more here.
Keywords: mode; mode mode; feedback loop; underexpanded jets ... See more keywords