Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abh1316
Abstract: Circadian rhythms play a critical role in regulating metabolism, including daily cycles of feeding/fasting. Glucokinase (GCK) is central for whole-body glucose homeostasis and oscillates according to a circadian clock. GCK activators (GKAs) effectively reduce hyperglycemia,… read more here.
Keywords: obese zucker; feeding periods; glucokinase; zucker rats ... See more keywords