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   Articles with "felodipine" as a keyword



Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-09733-1

Abstract: The vasodilatory and neuroprotective properties of felodipine were characterized in normal and ischemic rabbit eyes, an ocular hypertension (OHT) rat model, and cultured human neuron-like cells. Blood flow in the optic nerve head (ONH) was… read more here.

Keywords: felodipine; nerve head; via improved; blood circulation ... See more keywords

Mucoadhesive lyophilized wafers loaded with nano-spanlastic felodipine formulation: development and characterization

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-25230-x

Abstract: Felodipine (FDP) is used to treat hypertension and angina pectoris. FDP has an oral bioavailability of approximately 15% in humans, primarily due to its poor water solubility and extensive first-pass metabolism in the liver and… read more here.

Keywords: felodipine; mucoadhesive lyophilized; wafers loaded; loaded nano ... See more keywords

Tri-block co-polymer nanocarriers for enhancement of oral delivery of felodipine: preparation, in vitro characterization and ex vivo permeation

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recommendations! Published in 2018 at "Journal of Liposome Research"

DOI: 10.1080/08982104.2017.1327541

Abstract: Abstract This study aimed to prepare, optimize and characterize novel felodipine-loaded polymeric nanomicelles, using a pluronic mixture of F127 and P123. Thin-film hydration method was adopted for the preparation of different polymeric nanomicelles (T1–T12) according… read more here.

Keywords: felodipine; oral delivery; permeation; polymer ... See more keywords

Felodipine Promotes the Recovery of Mice With Spinal Cord Injury by Activating Macrolipophagy Through the AMPK‐mTOR Pathway

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recommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.70543

Abstract: Spinal cord injury (SCI) is a serious clinical condition characterised by extensive mechanical damage that compromises the tissue structure and microenvironment of the affected area. This damage leads to the formation of fibrotic blood vessels… read more here.

Keywords: cord; felodipine; ampk mtor; spinal cord ... See more keywords

Dry Gel Containing Optimized Felodipine-Loaded Transferosomes: a Promising Transdermal Delivery System to Enhance Drug Bioavailability

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recommendations! Published in 2018 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-018-1020-5

Abstract: Felodipine has a very low bioavailability due to first-pass metabolism. The aim of this study was to enhance its bioavailability by transdermal application. Felodipine-loaded transferosomes were prepared by thin-film hydration using different formulation variables. An… read more here.

Keywords: felodipine; formula; bioavailability; gel ... See more keywords

Development of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate -Indapamide Extended Release Tablets without Stationary (Felodipine) Basket.

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recommendations! Published in 2022 at "Current pharmaceutical design"

DOI: 10.2174/1381612828666220526122615

Abstract: BACKGROUND The dissolution method for certain drugs needs specialized conditions. Dissolution testing for felodipine extended release (ER) tablets (Plendil® 5mg) and amlodipine-indapamide fixed dose (Natrilam®, 5/1.5 mg) ER tablets require the use of a stationary… read more here.

Keywords: extended release; dissolution; felodipine basket; felodipine ... See more keywords

Impact of 14 types of genetic polymorphisms on antihypertensive efficacy of felodipine in healthy Chinese subjects
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recommendations! Published in 2020 at "International journal of clinical pharmacology and therapeutics"

DOI: 10.5414/cp203686

Abstract: OBJECTIVE This study evaluated different influences of 14 single nucleotide polymorphisms (SNPs) and demographic factors leading to individual differences in the antihypertensive efficacy of felodipine in healthy Chinese subjects. MATERIALS AND METHODS 24 subjects were… read more here.

Keywords: felodipine healthy; healthy chinese; chinese subjects; felodipine ... See more keywords