The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice
Sign Up to like & getrecommendations! Published in 2025 at "Brain and Behavior"
DOI: 10.1002/brb3.70573
Abstract: Targeting partial cellular reprogramming pathways through specific small molecule combinations holds promise for lifespan extension in model organisms. Chemical cocktails like RepSox and tranylcypromine (TCP) may induce beneficial age‐related changes without the risks of full… read more here.
Keywords: mice; combination two; molecules improves; small molecules ... See more keywords
Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4746
Abstract: We previously showed that the NO/cGMP/protein kinase G (PKG) signaling pathway positively regulates osteoblast proliferation, differentiation, and survival in vitro, and that cGMP‐elevating agents have bone‐anabolic effects in mice. Here, we generated mice with an… read more here.
Keywords: protein kinase; female mice; mechanical loading; bone ... See more keywords
BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25036
Abstract: Peripheral nerve regeneration is limited after injury, especially in humans, due to the large distance the axons have to grow in the limbs. This process is highly dependent on the expression of neuroinflammatory factors produced… read more here.
Keywords: female mice; inhibition; root ganglion; neurite outgrowth ... See more keywords
Female Mice Exposed to Pyriproxyfen Since Prepuberty Showed Reproductive Impairment During Sexual Maturity and Increased Fetal Death in Their Offspring
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DOI: 10.1002/tox.24374
Abstract: Pyriproxyfen (PPF) is an insecticide used in agriculture, which is approved for use in drinking water tanks for human consumption. However, some studies indicate that it may act as an endocrine disruptor and affect nontarget… read more here.
Keywords: mice; mice exposed; fetal death; exposed pyriproxyfen ... See more keywords
Role of Estradiol Receptor Beta (ERβ) on Arterial Pressure, Respiratory Chemoreflex and Mitochondrial Function in Young and Aged Female Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-91137-3_15
Abstract: We tested the hypothesis that ERβ is involved in respiratory control in female mice. We used young adult (5-6 months-old) and aged (17-18 months-old) ERβKO or wild-type controls (WT) female mice to assess arterial blood… read more here.
Keywords: blood pressure; arterial blood; female mice; mice ... See more keywords
Treatment with the Bifidobacterium longum Strain DSM 32947 Increases Bone Mineral Density in Female Mice
Sign Up to like & getrecommendations! Published in 2025 at "Calcified Tissue International"
DOI: 10.1007/s00223-025-01429-y
Abstract: Previous studies have shown that the gut microbiota regulates bone mass and that certain strains of Bifidobacterium longum prevent bone loss in ovariectomized (ovx) mice. A novel strain of Bifidobacterium longum (B. longum subsp. longum… read more here.
Keywords: mice; bifidobacterium longum; treatment; female mice ... See more keywords
Delayed cutaneous wound healing in young and old female mice is associated with differential growth factor release but not inflammatory cytokine secretion
Sign Up to like & getrecommendations! Published in 2025 at "Biogerontology"
DOI: 10.1007/s10522-024-10179-7
Abstract: The capacity for tissue repair during wound healing declines with age. A chronic low but systemic inflammatory status, often called “inflammaging”, is considered a key factor that contributes to impaired tissue regeneration. This phenomenon has… read more here.
Keywords: mice; wound healing; growth; female mice ... See more keywords
Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0447-y
Abstract: SummaryCoadministration of diclofenac and sunitinib, tyrosine kinase inhibitor, led to sex-divergent pharmacokinetic drug-drug interaction outcomes. Male and female mice were administered 60 mg/kg PO sunitinib alone (control groups) or with 30 mg/kg PO diclofenac. Sunitinib concentration in… read more here.
Keywords: sex divergent; male female; diclofenac; drug ... See more keywords
Translatability of mouse muscle-aging for humans: the role of sex
Sign Up to like & getrecommendations! Published in 2024 at "GeroScience"
DOI: 10.1007/s11357-024-01082-7
Abstract: Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have… read more here.
Keywords: muscle aging; muscle; aging related; sex ... See more keywords
Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-016-8826-6
Abstract: Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can… read more here.
Keywords: gardasil; hpv vaccine; female mice; aluminum adjuvants ... See more keywords
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.01.003
Abstract: Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is… read more here.
Keywords: immune functions; premature; female mice; mice ... See more keywords