Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4746
Abstract: We previously showed that the NO/cGMP/protein kinase G (PKG) signaling pathway positively regulates osteoblast proliferation, differentiation, and survival in vitro, and that cGMP‐elevating agents have bone‐anabolic effects in mice. Here, we generated mice with an… read more here.
Keywords: protein kinase; female mice; mechanical loading; bone ... See more keywords
BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25036
Abstract: Peripheral nerve regeneration is limited after injury, especially in humans, due to the large distance the axons have to grow in the limbs. This process is highly dependent on the expression of neuroinflammatory factors produced… read more here.
Keywords: female mice; inhibition; root ganglion; neurite outgrowth ... See more keywords
Role of Estradiol Receptor Beta (ERβ) on Arterial Pressure, Respiratory Chemoreflex and Mitochondrial Function in Young and Aged Female Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-91137-3_15
Abstract: We tested the hypothesis that ERβ is involved in respiratory control in female mice. We used young adult (5-6 months-old) and aged (17-18 months-old) ERβKO or wild-type controls (WT) female mice to assess arterial blood… read more here.
Keywords: blood pressure; arterial blood; female mice; mice ... See more keywords
Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0447-y
Abstract: SummaryCoadministration of diclofenac and sunitinib, tyrosine kinase inhibitor, led to sex-divergent pharmacokinetic drug-drug interaction outcomes. Male and female mice were administered 60 mg/kg PO sunitinib alone (control groups) or with 30 mg/kg PO diclofenac. Sunitinib concentration in… read more here.
Keywords: sex divergent; male female; diclofenac; drug ... See more keywords
Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-016-8826-6
Abstract: Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can… read more here.
Keywords: gardasil; hpv vaccine; female mice; aluminum adjuvants ... See more keywords
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.01.003
Abstract: Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is… read more here.
Keywords: immune functions; premature; female mice; mice ... See more keywords
Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.08.225
Abstract: There is significant variability in the expression of cancer-related fatigue. Understanding the factors that account for this variation provide insight into the underlying mechanisms. One important, but often overlooked, variable is biological sex. While a… read more here.
Keywords: sex differences; sex; female mice; mice ... See more keywords
Improvement of APOE4-dependent non-cognitive behavioural traits by postnatal cholinergic stimulation in female mice
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112552
Abstract: The apolipoprotein E (APOE) ɛ4 allele hastens cognitive decline, but other non-cognitive behaviours, as well as underpinning interactions with the cholinergic system, have not been systematically addressed. Both C57BL/6 and humanised apoE4 female mice were… read more here.
Keywords: non cognitive; female mice; mice; cpf ... See more keywords
Estrogen receptor α mediated M1/M2 macrophages polarization plays a critical role in NASH of female mice.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.085
Abstract: Owing to lacking protective effect of estrogen, OVX mice have higher risk of non-alcoholic fatty liver disease compared with normal female mice, when fed with high fat diet. Our study was to explore how estrogen… read more here.
Keywords: mice; female mice; role; estrogen ... See more keywords
NFAT5 contributes to the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and decrease of T regulatory cells in female mice.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2022.104515
Abstract: Multiple sclerosis disproportionally affects women. The present study was undertaken to determine whether NFAT5 contributed to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, and if it did, whether the impact… read more here.
Keywords: eae; experimental autoimmune; female mice; autoimmune encephalomyelitis ... See more keywords
A human exposure based mixture of persistent organic pollutants affects the stress response in female mice and their offspring.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.01.085
Abstract: Persistent organic pollutants (POPs) are found in the food chain of both humans and animals and exert a wide spectrum of potentially adverse effects. The present experiment aimed to investigate whether a defined mixture of… read more here.
Keywords: organic pollutants; response; persistent organic; female mice ... See more keywords