Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor
Sign Up to like & getrecommendations! Published in 2024 at "Birth Defects Research"
DOI: 10.1002/bdr2.2345
Abstract: Abrocitinib is a Janus kinase (JAK) 1 selective inhibitor approved for the treatment of atopic dermatitis. Female reproductive tissues were unaffected in general toxicity studies, but an initial female rat fertility study resulted in adverse… read more here.
Keywords: fertility; rat fertility; janus kinase; abrocitinib janus ... See more keywords
Female rat transcriptome response to infraorbital nerve transection differs from that of males: RNA‐seq
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24045
Abstract: The effects of infraorbital nerve (ION) transection on gene expression in the adult female rat barrel cortex were investigated using RNA sequencing. After a 24‐hour survival duration, 28 genes were differentially regulated by ION transection.… read more here.
Keywords: rna seq; female rat; transection; infraorbital nerve ... See more keywords
(-)-Epicatechin Ameliorates Cardiac Fibrosis in a Female Rat Model of Pre-Heart Failure with Preserved Ejection Fraction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal food"
DOI: 10.1089/jmf.2021.0158
Abstract: One of the most abundant flavonoids present in cacao is (-)-epicatechin (Epi) and this flavanol has been linked to the cardiovascular health promoting actions of cocoa products. We previously demonstrated that Epi reduces infarct size… read more here.
Keywords: female rat; rat model; fraction; fibrosis ... See more keywords
Effects of Adult Female Rat Androgenization on Brain Morphology and Metabolomic Profile
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhx163
Abstract: Androgenization in adult natal women, as in transsexual men (TM), affects brain cortical thickness and the volume of subcortical structures. In order to understand the mechanism underlying these changes we have developed an adult female… read more here.
Keywords: androgenization; adult female; female rat; effects adult ... See more keywords
Progesterone Protects Against Bisphenol A–Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1702
Abstract: Bisphenol A (BPA) is an estrogenic endocrine-disrupting chemical (EDC) that has a range of potential adverse health effects. Previously we showed that acute exposure to BPA promoted arrhythmias in female rat hearts through estrogen receptor… read more here.
Keywords: cardiac myocytes; arrhythmias female; bpa; rapid signaling ... See more keywords
Acute and chronic effects by nicotine on striatal neurotransmission and synaptic plasticity in the female rat brain
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1104648
Abstract: Introduction Tobacco use is in part a gendered activity, yet neurobiological studies outlining the effect by nicotine on the female brain are scarce. The aim of this study was to outline acute and sub-chronic effects… read more here.
Keywords: neurotransmission; nicotine; brain; female rat ... See more keywords
Influence of Maternal Diet and Intergenerational Change in Diet Type on Ovarian and Adipose Tissue Morphology in Female Rat Offspring
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58070854
Abstract: Background and Objectives: A high-fat diet causes inflammation in the organism and many metabolic disorders. Adipose tissue secretes adipokines that affect the function of many organs. The health status of the mother before and during… read more here.
Keywords: female rat; maternal diet; adipose tissue; high fat ... See more keywords
Therapeutic Effects of Photobiomodulation Therapy on Ovarian Structure and GDF9, BMP15 and BMP4 Expression in the Spinal Cord Injury Female Rat Model.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of lasers in medical sciences"
DOI: 10.34172/jlms.2025.12
Abstract: Introduction: Spinal cord injury (SCI) often results in severe neurological deficits and secondary complications, including disruptions in female reproductive health. Current treatment options are limited in addressing both neurological recovery and reproductive outcomes. This study… read more here.
Keywords: cord; spinal cord; cord injury; photobiomodulation therapy ... See more keywords
Maternal Exposure to D-galactose Reduces Ovarian Reserve in Female Rat Offspring Later in Life
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology and Metabolism"
DOI: 10.5812/ijem-123206
Abstract: Background Embryonic life is critical for the formation of ovaries in mammals, and the intrauterine environment may affect ovarian reserve. Objectives The present study aimed to investigate the impact of prenatal D-galactose exposure on ovarian… read more here.
Keywords: ovarian reserve; offspring later; reserve female; female rat ... See more keywords