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   Articles with "femo cofactor" as a keyword



The nitrogenase mechanism: new roles for the dangler?

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recommendations! Published in 2024 at "Journal of Biological Inorganic Chemistry"

DOI: 10.1007/s00775-024-02085-7

Abstract: Dangler sites protruding from a core metallocluster were introduced into the bioinorganic lexicon in 2000 by R.D. Britt and co-workers in an analysis of the tetramanganese oxygen-evolving cluster in photosystem II. In this perspective, we… read more here.

Keywords: dangler; femo cofactor; nitrogenase; nitrogenase mechanism ... See more keywords

Mechanistic Insights into Nitrogenase FeMo-Cofactor Catalysis through a Steady-State Kinetic Model.

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00415

Abstract: Mo-nitrogenase catalyzes the challenging N2-to-NH3 reduction. This complex reaction proceeds through a series of intermediate states (En) of its active site FeMo-cofactor. An understanding of the kinetics of the conversion between En states is central… read more here.

Keywords: rate; state; nitrogenase; femo cofactor ... See more keywords

13C ENDOR Characterization of the Central Carbon within the Nitrogenase Catalytic Cofactor Indicates That the CFe6 Core Is a Stabilizing "Heart of Steel".

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c06149

Abstract: Substrates and inhibitors of Mo-dependent nitrogenase bind and react at Fe ions of the active-site FeMo-cofactor [7Fe-9S-C-Mo-homocitrate] contained within the MoFe protein α-subunit. The cofactor contains a CFe6 core, a carbon centered within a trigonal… read more here.

Keywords: cfe6 core; carbon; cofactor; endor ... See more keywords

Structural evolution of nitrogenase states under alkaline turnover

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54713-0

Abstract: Biological nitrogen fixation, performed by the enzyme nitrogenase, supplies nearly 50% of the bioavailable nitrogen pool on Earth, yet the structural nature of the enzyme intermediates involved in this cycle remains ambiguous. Here we present… read more here.

Keywords: alkaline turnover; femo cofactor; nitrogenase; nitrogen fixation ... See more keywords