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   Articles with "fen1" as a keyword



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FEN1 promotes tumor progression and confers cisplatin resistance in non‐small‐cell lung cancer

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recommendations! Published in 2017 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12118

Abstract: Lung cancer is one of the leading causes of cancer mortality worldwide. The therapeutic effect of chemotherapy is limited due to the resistance of cancer cells, which remains a challenge in cancer therapeutics. In this… read more here.

Keywords: fen1; lung cancer; resistance; cancer cells ... See more keywords
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Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening.

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recommendations! Published in 2017 at "Molecular bioSystems"

DOI: 10.1039/c7mb00118e

Abstract: Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomide, MMS,… read more here.

Keywords: fen1; fen1 inhibitors; machine learning; human flap ... See more keywords
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Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1

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recommendations! Published in 2019 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.mct-18-1215

Abstract: DNA repair mechanisms are crucial for cell survival. It increases the cancer cell's ability to resist DNA damage. FEN1 is involved in DNA replication and repair, specifically long-patch base excision repair. Although the gene function… read more here.

Keywords: cancer cells; fen1; lung cancer; cancer ... See more keywords
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RNA G-Quadruplex within the 5′-UTR of FEN1 Regulates mRNA Stability under Oxidative Stress

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12020276

Abstract: Reactive oxygen species (ROS) are a group of highly oxidative molecules that induce DNA damage, affecting DNA damage response (DDR) and gene expression. It is now recognized that DNA base excision repair (BER) is one… read more here.

Keywords: utr fen1; oxidative stress; fen1; rna quadruplex ... See more keywords