Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening.
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DOI: 10.1039/c7mb00118e
Abstract: Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomide, MMS,… read more here.
Keywords: fen1; fen1 inhibitors; machine learning; human flap ... See more keywords