Effect of fenfluramine on seizures and comorbidities in SCN8A‐developmental and epileptic encephalopathy: A case series
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DOI: 10.1002/epi4.12623
Abstract: SCN8A‐developmental and epileptic encephalopathy is caused by pathogenic variants in the SCN8A gene encoding the Nav1.6 sodium channel, and is characterized by intractable multivariate seizures and developmental regression. Fenfluramine is a repurposed drug with proven… read more here.
Keywords: developmental epileptic; scn8a developmental; effect fenfluramine; fenfluramine ... See more keywords
Fenfluramine for seizures associated with Sunflower syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental medicine and child neurology"
DOI: 10.1111/dmcn.14965
Abstract: AIM To determine the efficacy of fenfluramine on seizure frequency in patients with Sunflower syndrome. Secondary endpoints were changes in electroencephalogram (EEG) characteristics, cognitive functioning, executive functioning, and quality of life. METHOD In this open-label… read more here.
Keywords: fenfluramine seizures; sunflower syndrome; fenfluramine; treatment ... See more keywords
Therapeutic drug monitoring of fenfluramine in clinical practice: Pharmacokinetic variability and impact of concomitant antiseizure medications
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17162
Abstract: This study was undertaken to determine the plasma concentration and pharmacokinetic variability of fenfluramine (FFA) and its main active metabolite norfenfluramine (norFFA) in relation to the prevalence of adverse effects in patients with refractory epilepsy… read more here.
Keywords: concomitant antiseizure; fenfluramine; antiseizure medications; pharmacokinetic variability ... See more keywords