Influence of St. John’s Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects
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DOI: 10.1097/aln.0000000000003065
Abstract: Background: Patients often use complementary and alternative herbal medicines, hence, potential exists for adverse herb–drug interactions. Fentanyl is metabolized by hepatic CYP3A4 and considered transported by blood–brain barrier P-glycoprotein. Both disposition processes could be upregulated… read more here.
Keywords: john wort; fentanyl pharmacokinetics; wort; pharmacokinetics pharmacodynamics ... See more keywords
P50 Individual variations in fentanyl pharmacokinetics and pharmacodynamics in preterm infants
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-esdppp.88
Abstract: Background Fentanyl pharmacokinetics and pharmacodynamics are lacking in preterm infants. Our aim was to study these and their relation with a new formulation of fentanyl 5 mg/mL for procedural pain. Methods Preterm infants were given… read more here.
Keywords: p50 individual; variations fentanyl; individual variations; pharmacokinetics pharmacodynamics ... See more keywords