A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
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DOI: 10.1038/s41467-017-00832-w
Abstract: Disruption of the reprogrammed energy management system of malignant cells is a prioritized goal of targeted cancer therapy. Two regulators of this system are the Fer kinase, and its cancer cell specific variant, FerT, both… read more here.
Keywords: death; malignant cells; metabolic stress; fer fert ... See more keywords
Abstract 3078: The fer/FerT cell survival pathway of the ancestral sponge (Sycon raphanus) becomes a mitochondrial proto-oncogene in the human genome
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3078
Abstract: The Fer/FerT (truncated) genes and their encoded 879 aa / 100 kDa proteins (fujinami poultry sarcoma; feline sarcoma-related kinases) were discovered in the sponge Sycon raphanus [1]. The recognition of other related genes and their… read more here.
Keywords: cell survival; cancer; fer fert;
Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells
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DOI: 10.3390/ijms24065256
Abstract: Fer and its sperm and cancer specific variant, FerT, are non-receptor tyrosine kinases which play roles in cancer progression and metastasis. Recent studies have shed light on the regulatory role of these kinases in ensuring… read more here.
Keywords: fer fert; cancer cells; fert new; sperm cancer ... See more keywords