Exchangeable proton ENDOR as a probe of the redox-active iron center in activated bleomycin and ferric bleomycin.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt01354j
Abstract: Activated bleomycin (ABLM) is a drug-Fe(iii)-hydroperoxide complex kinetically competent in DNA attack (via H4' abstraction). This intermediate is relatively stable, but its spontaneous conversion to ferric bleomycin (Fe(iii)·BLM) is poorly characterized because no observable intermediate… read more here.
Keywords: activated bleomycin; proton; endor; ferric bleomycin ... See more keywords