Simple plant‐based production and purification of the assembled human ferritin heavy chain as a nanocarrier for tumor‐targeted drug delivery and bioimaging in cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28312
Abstract: Nanoparticles are used as carriers for the delivery of drugs and imaging agents. Proteins are safer than synthetic nanocarriers due to their greater biocompatibility and the absence of toxic degradation products. In this context, ferritin… read more here.
Keywords: human ferritin; heavy chain; production; delivery ... See more keywords
Electroinduced Extraction of Human Ferritin Heavy Chain Expressed in Hansenula polymorpha
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DOI: 10.1007/s12010-017-2627-9
Abstract: AbstractА protocol for the efficient and selective recovery of human ferritin heavy chain (FTH1) expressed intracellularly in Hansenula polymorpha was developed. It was based on electropermeabilisation and an increase in the cell wall porosity by… read more here.
Keywords: ferritin heavy; heavy chain; human ferritin; polymorpha ... See more keywords
Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.173
Abstract: Hypoxia-inducible factor 1 (HIF-1) is a key player in cellular response to hypoxia. The stability and transcriptional activity of this protein are oxygen-dependently regulated by the prolyl hydroxylases PHD1-3 and the asparaginyl hydroxylase FIH. Recently,… read more here.
Keywords: ferritin heavy; hif; asparaginyl hydroxylase; heavy chain ... See more keywords
Development of robust and facile purification process for production of recombinant human ferritin heavy chain nanoparticle from Escherichia coli
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DOI: 10.1016/j.procbio.2021.02.014
Abstract: Abstract Recombinant human ferritin heavy chain (rhFTH) was highly expressed and self-assembled in E. coli bacteria. To establish a robust purification scheme, we developed a non-chromatographic precipitation procedure as a key step for extracting rhFTH… read more here.
Keywords: human ferritin; ferritin heavy; recombinant human; heavy chain ... See more keywords
Molecular Characterization and Functional Analysis of a Ferritin Heavy Chain Subunit from the Eri-Silkworm, Samia cynthia ricini
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DOI: 10.3390/ijms18102126
Abstract: Ferritins are conserved iron-binding proteins that are primarily involved in iron storage, detoxification and the immune response. Despite the importance of ferritin in organisms, little is known about their roles in the eri-silkworm (Samia cynthia… read more here.
Keywords: ferritin heavy; chain; chain subunit; heavy chain ... See more keywords
Counteraction of Myocardial Ferritin Heavy Chain Deficiency by Heme Oxygenase-1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158300
Abstract: Given the abundance of heme proteins (cytochromes) in the mitochondrion, it is evident that a meticulously orchestrated iron metabolism is essential for cardiac health. Here, we examined the functional significance of myocardial ferritin heavy chain… read more here.
Keywords: heavy chain; deletion; fth deletion; heme oxygenase ... See more keywords
Nuclear Factor Kappa B Promotes Ferritin Heavy Chain Expression in Bombyx mori in Response to B. mori Nucleopolyhedrovirus Infection
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DOI: 10.3390/ijms231810380
Abstract: Ferritin heavy chain (FerHCH) is a major component of ferritin and plays an important role in maintaining iron homeostasis and redox equilibrium. Our previous studies have demonstrated that the Bombyx mori ferritin heavy chain homolog… read more here.
Keywords: heavy chain; bmnpv infection; infection; expression ... See more keywords
Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration
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DOI: 10.3390/ijms232112987
Abstract: The H Ferritin subunit (FTH1), as well as regulating the homeostasis of intracellular iron, is involved in complex pathways that might promote or inhibit carcinogenesis. This function may be mediated by its ability to interact… read more here.
Keywords: proliferation migration; cell proliferation; proliferation; fth1 ... See more keywords