Epigenetic Regulation of Ferroportin in Primary Cultures of the Rat Blood-Brain Barrier
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01953-y
Abstract: Ferroportin plays an essential role for iron transport through the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). To maintain the integrity of the BBB, the BCECs gain support from pericytes… read more here.
Keywords: blood brain; ferroportin; expression; brain barrier ... See more keywords
Structural basis of ion transport and inhibition in ferroportin
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19458-6
Abstract: Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation… read more here.
Keywords: structural basis; transport inhibition; ferroportin; transport ... See more keywords
Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14933-5
Abstract: Hepcidin is a small cysteine rich peptide that regulates the sole known cellular iron exporter, ferroportin, effectively controlling iron metabolism. Contrary to humans, where a single hepcidin exists, many fish have two functionally distinct hepcidin… read more here.
Keywords: fish two; ferroportin; hepcidin; iron ... See more keywords
Ferroportin Downregulation Promotes Cell Proliferation By Modulating the Nrf2-Mir 17-5p Axis in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131679
Abstract: Recent findings demonstrate that aberrant downregulation of the iron-exporter protein, ferroportin (FPN1), is associated with poor prognosis and osteoclast differentiation in multiple myeloma (MM). Here, we show that FPN1 was downregulated in MM and that… read more here.
Keywords: cell proliferation; ferroportin; mir; multiple myeloma ... See more keywords
UBA6 and NDFIP1 regulate the degradation of ferroportin.
Sign Up to like & getrecommendations! Published in 2021 at "Haematologica"
DOI: 10.3324/haematol.2021.278530
Abstract: Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells. Binding of hepcidin to ferroportin induces the ubiquitination of ferroportin at multiple lysine… read more here.
Keywords: degradation; components ubiquitin; ferroportin; hepcidin ... See more keywords
Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02123
Abstract: The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively… read more here.
Keywords: anemia; ferroportin; treatment; pregnant women ... See more keywords
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031060
Abstract: Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Down syndrome (DS) dementia. However, the mechanisms of iron deposition and… read more here.
Keywords: ferroportin; iron; brain; ageing brain ... See more keywords
Mechanism of Ca2+ transport by ferroportin
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.82947
Abstract: Ferroportin (Fpn) is a transporter that releases Fe2+ from cells and is important for iron homeostasis in circulation. Export of Fe2+ by Fpn is coupled to import of H+ to maintain charge balance. Although Ca2+… read more here.
Keywords: ferroportin; fpn; ca2 transport; transport ... See more keywords